Display Settings:

Format

Send to:

Choose Destination

SCRIB scribbled planar cell polarity protein [ Homo sapiens (human) ]

Gene ID: 23513, updated on 12-Feb-2015
Official Symbol
SCRIBprovided by HGNC
Official Full Name
scribbled planar cell polarity proteinprovided by HGNC
Primary source
HGNC:HGNC:30377
See related
Ensembl:ENSG00000180900; HPRD:06984; MIM:607733; Vega:OTTHUMG00000165154
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRIB1; SCRB1; SCRIB1; Vartul
Summary
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Orthologs
See SCRIB in MapViewer
Location:
8q24.3
Exon count:
37
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 8 NC_000008.11 (143790920..143815379, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144873090..144897890, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene UPF0454 protein C12orf49-like Neighboring gene putative IQ motif and ankyrin repeat domain-containing protein LOC642574-like Neighboring gene microRNA 937 Neighboring gene poly-U binding splicing factor 60KDa Neighboring gene nuclear receptor binding protein 2 Neighboring gene microRNA 6845

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Asymmetric localization of PCP proteins, organism-specific biosystem (from REACTOME)
    Asymmetric localization of PCP proteins, organism-specific biosystemOne of the hallmarks of the Planar Cell Polarity pathway is the asymmetric distribution of proteins on opposite membranes of a single cell. In Drosophila, Stbm and Pk (homologues to the human VANGL1/...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • PCP/CE pathway, organism-specific biosystem (from REACTOME)
    PCP/CE pathway, organism-specific biosystemThe planar cell polarity (PCP) pathway controls the establishment of polarity within the plane of a sheet of cells. PCP was initially characterized in Drosophila, where it controls the arrangement o...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
  • TSH signaling pathway, organism-specific biosystem (from WikiPathways)
    TSH signaling pathway, organism-specific biosystemHuman thyroid stimulating hormone (TSH) is a glycoprotein secreted by the anterior part of the pituitary gland (1). TSH plays an important physiological role in the regulation of the hypothalamic-pit...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • beta-catenin independent WNT signaling, organism-specific biosystem (from REACTOME)
    beta-catenin independent WNT signaling, organism-specific biosystemHumans and mice have 19 identified WNT proteins that were originally classified as either 'canonical' or 'non-canonical' depending upon whether they were able to transform the mouse mammary epithelia...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
astrocyte cell migration IEA
Inferred from Electronic Annotation
more info
 
asymmetric protein localization IEA
Inferred from Electronic Annotation
more info
 
auditory receptor cell stereocilium organization IEA
Inferred from Electronic Annotation
more info
 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cochlear nucleus development IEA
Inferred from Electronic Annotation
more info
 
establishment of apical/basal cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland duct morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to adherens junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
single organismal cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle targeting IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Scrib-APC-beta-catenin complex IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
myelin sheath abaxonal region IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein scribble homolog
Names
protein scribble homolog
scribbled homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030583.1 RefSeqGene

    Range
    5001..29460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015356.4NP_056171.3  protein scribble homolog isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF240677, AI829609, AY062238, BC014632
    Consensus CDS
    CCDS6411.1
    UniProtKB/Swiss-Prot
    Q14160
    Related
    ENSP00000322938, OTTHUMP00000228641, ENST00000320476, OTTHUMT00000382215
    Conserved Domains (4) summary
    COG4886
    Location:39401
    COG4886; Leucine-rich repeat (LRR) protein [Function unknown]
    cd00116
    Location:12232
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00992
    Location:10021090
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12799
    Location:290329
    LRR_4; Leucine Rich repeats (2 copies)
  2. NM_182706.4NP_874365.3  protein scribble homolog isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI829609, AY062238, BC009490, BC014632, BC044627
    Consensus CDS
    CCDS6412.1
    UniProtKB/TrEMBL
    A0PJK8
    UniProtKB/Swiss-Prot
    Q14160
    Related
    ENSP00000349486, OTTHUMP00000228640, ENST00000356994, OTTHUMT00000382214
    Conserved Domains (4) summary
    COG4886
    Location:39401
    COG4886; Leucine-rich repeat (LRR) protein [Function unknown]
    cd00116
    Location:12232
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00992
    Location:10021090
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12799
    Location:290329
    LRR_4; Leucine Rich repeats (2 copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38 Primary Assembly

    Range
    143790920..143815379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_1

Genomic

  1. NT_187571.1 Reference GRCh38 ALT_REF_LOCI_1

    Range
    267967..292426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    144913332..144937791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000140.1 Alternate HuRef

    Range
    140126075..140150540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)