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    Thy1 thymus cell antigen 1, theta [ Mus musculus (house mouse) ]

    Gene ID: 21838, updated on 7-Feb-2016
    Official Symbol
    Thy1provided by MGI
    Official Full Name
    thymus cell antigen 1, thetaprovided by MGI
    Primary source
    MGI:MGI:98747
    See related
    Ensembl:ENSMUSG00000032011; Vega:OTTMUSG00000016734
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T25; CD90; Thy-1; Thy1.1; Thy1.2; Thy-1.2
    Summary
    This gene encodes a glycoprotein that is anchored to the cell surface of thymocytes, neuronal and other cells through a glycosyl-phosphatidylinositol moiety. A soluble form of the encoded protein has also been detected in serum and cerebrospinal fluid. The encoded protein undergoes further processing to generate the mature protein which mediates cell-cell interactions to trigger downstream signaling pathways. [provided by RefSeq, Jul 2015]
    Orthologs
    See Thy1 in Epigenomics, MapViewer
    Location:
    9 A5.1; 9 24.52 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (44043384..44048579)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (43851467..43856662)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30373 Neighboring gene predicted gene, 39323 Neighboring gene predicted gene, 39325 Neighboring gene ubiquitin specific peptidase 2 Neighboring gene predicted gene, 38444

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GPI anchor binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    retinal cone cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    single organismal cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    anchored component of external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    anchored component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    thy-1 membrane glycoprotein
    Names
    thy-1 antigen

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009382.3NP_033408.1  thy-1 membrane glycoprotein preproprotein

      See identical proteins and their annotated locations for NP_033408.1

      Status: REVIEWED

      Source sequence(s)
      AC126459, AK003006, BF455369, CD776453, CJ043838
      Consensus CDS
      CCDS23093.1
      UniProtKB/Swiss-Prot
      P01831
      Related
      ENSMUSP00000110489, OTTMUSP00000018127, ENSMUST00000114840, OTTMUST00000040558
      Conserved Domains (2) summary
      smart00406
      Location:33106
      IGv; Immunoglobulin V-Type
      smart00410
      Location:30111
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

      Range
      44043384..44048579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000031.1 Alternate Mm_Celera

      Range
      41300956..41306126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)