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SIRT1 sirtuin 1 [ Homo sapiens (human) ]

Gene ID: 23411, updated on 7-Jul-2014
Official Symbol
SIRT1provided by HGNC
Official Full Name
sirtuin 1provided by HGNC
Primary source
HGNC:14929
Locus tag
RP11-57G10.3
See related
Ensembl:ENSG00000096717; HPRD:08381; MIM:604479; Vega:OTTHUMG00000018340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2L1
Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
See SIRT1 in Epigenomics, MapViewer
Location:
10q21.3
Exon count :
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (67884669..67918390)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (69644427..69678147)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 12 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 19 pseudogene 1 Neighboring gene ribosomal protein L12 pseudogene 8 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 4 Neighboring gene ribosomal protein S3a pseudogene 38 Neighboring gene POU class 5 homeobox 1 pseudogene 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat HIV-1 Tat upregulates miR-182 in TZM-bl cells, which results in downregulation of SIRT1 protein expression and activity by MiR-182 PubMed
tat HIV-1 Tat inhibits SIRT1 and increases acetylation of p53, which leads to activation of p21 and BAX in HeLa-CD4+ cells PubMed
tat HIV-1 Tat modulates SIRT1 expression in neuron cells PubMed
tat HIV-1 Tat upregulates miR-34a in TZM-bl cells, which results in downregulation of SIRT1 protein expression and activity and induction of NFkappaB p65 acetylation by MiR-34a PubMed
tat HIV-1 Tat-induced expression of miR-217 downregulates SIRT1 and promotes HIV-1 LTR transactivation in MAGI cells PubMed
tat HIV-1 Tat is identified to have a physical interaction with sirtuin 1 (SIRT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
tat Tat causes NAD(+) depletion and inhibits Nicotinamide phosphoribosyltransferase (Nampt) mRNA and protein expression in cells. Nampt is critical in the regulation of Tat-induced inhibition of sirtuin 1 (SIRT1) activity and LTR transactivation PubMed
tat HIV-1 Tat binds the deacetylase domain (amino acids 341-512) of SIRT1 and inhibits SIRT1 deacetylase activity, which results in the induction of NF-kappaB hyperacetylation PubMed
tat Overexpression of SIRT1 attenuates Tat-induced HIV-1 transcription in MAGI cells PubMed
tat Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) PubMed
tat Deacetylation of HIV-1 Tat by human sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent class III protein deacetylase, regulates Tat transactivation of the HIV-1 promoter PubMed

Go to the HIV-1, Human Protein Interaction Database

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Amphetamine addiction, organism-specific biosystem (from KEGG)
    Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Amphetamine addiction, conserved biosystem (from KEGG)
    Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
  • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
    Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    E2F transcription factor network, organism-specific biosystem
    E2F transcription factor network
  • Energy Metabolism, organism-specific biosystem (from WikiPathways)
    Energy Metabolism, organism-specific biosystemThe PPARGC1A protein is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPARG, which permits the interaction of ...
  • Epigenetic regulation of gene expression, organism-specific biosystem (from REACTOME)
    Epigenetic regulation of gene expression, organism-specific biosystemEpigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA se...
  • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
    FoxO family signaling, organism-specific biosystem
    FoxO family signaling
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • HIF-2-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    HIF-2-alpha transcription factor network, organism-specific biosystem
    HIF-2-alpha transcription factor network
  • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Negative epigenetic regulation of rRNA expression, organism-specific biosystem (from REACTOME)
    Negative epigenetic regulation of rRNA expression, organism-specific biosystemTranscription of rRNA genes is controlled by epigenetic activation and repression (reviewed in McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2013). About half of the roughl...
  • Regulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Androgen receptor activity, organism-specific biosystem
    Regulation of Androgen receptor activity
  • Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
    Regulation of HSF1-mediated heat shock response, organism-specific biosystemThe ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomer...
  • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of retinoblastoma protein, organism-specific biosystem
    Regulation of retinoblastoma protein
  • SIRT1 negatively regulates rRNA Expression, organism-specific biosystem (from REACTOME)
    SIRT1 negatively regulates rRNA Expression, organism-specific biosystemExpression of rRNA genes is coupled to the overall metabolism of the cell by the NAD-dependent histone deacetylase SIRT1, a component of the Energy-dependent Nucleolar Silencing Complex (eNoSC) (Mura...
  • SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystem (from WikiPathways)
    SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystemThis pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders N??r.
  • SREBP signalling, organism-specific biosystem (from WikiPathways)
    SREBP signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...
  • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class I, organism-specific biosystem
    Signaling events mediated by HDAC Class I
  • Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class III, organism-specific biosystem
    Signaling events mediated by HDAC Class III
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
HLH domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent histone deacetylase activity (H3-K9 specific) ISS
Inferred from Sequence or Structural Similarity
more info
 
NAD-dependent protein deacetylase activity IDA
Inferred from Direct Assay
more info
 
NAD-dependent protein deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
bHLH transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
 
histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase activity IDA
Inferred from Direct Assay
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
keratin filament binding IPI
Inferred from Physical Interaction
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase binding IPI
Inferred from Physical Interaction
more info
 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
DNA repair TAS
Traceable Author Statement
more info
PubMed 
DNA replication TAS
Traceable Author Statement
more info
PubMed 
DNA synthesis involved in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 
angiogenesis IDA
Inferred from Direct Assay
more info
 
cell aging TAS
Traceable Author Statement
more info
PubMed 
cellular glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
 
cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 
cellular response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
cellular triglyceride homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatin organization IMP
Inferred from Mutant Phenotype
more info
 
chromatin silencing TAS
Traceable Author Statement
more info
PubMed 
chromatin silencing at rDNA IDA
Inferred from Direct Assay
more info
PubMed 
establishment of chromatin silencing IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
histone H3 deacetylation IDA
Inferred from Direct Assay
more info
 
histone H3 deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 
maintenance of chromatin silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
methylation-dependent chromatin silencing TAS
Traceable Author Statement
more info
 
muscle organ development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of androgen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 
negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cellular response to testosterone stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cellular senescence IDA
Inferred from Direct Assay
more info
 
negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptidyl-lysine acetylation IDA
Inferred from Direct Assay
more info
 
negative regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of prostaglandin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of sequence-specific DNA binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
ovulation from ovarian follicle IEA
Inferred from Electronic Annotation
more info
 
peptidyl-lysine acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-lysine deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MHC class II biosynthetic process IDA
Inferred from Direct Assay
more info
 
positive regulation of adaptive immune response IDA
Inferred from Direct Assay
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cAMP-dependent protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of cellular senescence IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of chromatin silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone H3-K9 methylation IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 
positive regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macrophage apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 
NOT protein ADP-ribosylation TAS
Traceable Author Statement
more info
PubMed 
protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
protein deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein destabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
 
pyrimidine dimer repair by nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 
rRNA processing IEA
Inferred from Electronic Annotation
more info
 
regulation of bile acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of endodeoxyribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of peroxisome proliferator activated receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein import into nucleus, translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of smooth muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
response to insulin ISS
Inferred from Sequence or Structural Similarity
more info
 
response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
single strand break repair IMP
Inferred from Mutant Phenotype
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
triglyceride mobilization ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
white fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
colocalizes_with ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
PML body IDA
Inferred from Direct Assay
more info
PubMed 
chromatin silencing complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
NOT cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
rDNA heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
NAD-dependent protein deacetylase sirtuin-1
Names
NAD-dependent protein deacetylase sirtuin-1
hSIR2
hSIRT1
SIR2alpha
sir2-like 1
sirtuin type 1
SIR2-like protein 1
regulatory protein SIR2 homolog 1
NAD-dependent deacetylase sirtuin-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142498.1NP_001135970.1  NAD-dependent protein deacetylase sirtuin-1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform b has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AA452304, AK289743, BC012499, DB162635
    Consensus CDS
    CCDS44412.1
    UniProtKB/TrEMBL
    A8K128
    UniProtKB/TrEMBL
    E9PC49
    UniProtKB/Swiss-Prot
    Q96EB6
    Related
    ENSP00000409208, ENST00000432464
    Conserved Domains (1) summary
    cl00195
    Location:1194
    Blast Score: 888
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  2. NM_012238.4NP_036370.2  NAD-dependent protein deacetylase sirtuin-1 isoform a

    See proteins identical to NP_036370.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA452304, AF083106, BC012499
    Consensus CDS
    CCDS7273.1
    UniProtKB/Swiss-Prot
    Q96EB6
    Related
    ENSP00000212015, OTTHUMP00000019691, ENST00000212015, OTTHUMT00000048296
    Conserved Domains (1) summary
    cd01408
    Location:254489
    Blast Score: 1077
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    67884669..67918390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717737.1XP_006717800.1  

    Conserved Domains (1) summary
    cl00195
    Location:262438
    Blast Score: 789
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  2. XM_005269663.1XP_005269720.1  

    See proteins identical to XP_005269720.1

    UniProtKB/TrEMBL
    B0QZ35
    Related
    ENSP00000384508, OTTHUMP00000198112, ENST00000406900, OTTHUMT00000048297
    Conserved Domains (1) summary
    cl00195
    Location:12186
    Blast Score: 785
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    63643871..63677731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    69926404..69960153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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