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Npy neuropeptide Y [ Rattus norvegicus (Norway rat) ]

Gene ID: 24604, updated on 3-Jun-2014
Official Symbol
Npyprovided by RGD
Official Full Name
neuropeptide Yprovided by RGD
Primary source
RGD:3197
See related
Ensembl:ENSRNOG00000009768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
NPY02; RATNPY; RATNPY02
Summary
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. Studies in the rat model of depression (Flinders Sensitive Line) show that this gene is downregulated in the hippocampus and the prefrontal cortex compared to the control ((Flinders Resistant Line). Alternatively spliced transcript variants of this gene have been described, but the function of all the variants is not known. [provided by RefSeq, Jul 2012]
See Npy in MapViewer
Location:
4q24
Exon count :
4
Annotation release Status Assembly Chr Location
104 current Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (144233753..144240956)

Chromosome 4 - NC_005103.3Genomic Context describing neighboring genes Neighboring gene RGD1564712 Neighboring gene uncharacterized LOC102555544 Neighboring gene pro-neuropeptide Y-like Neighboring gene uncharacterized LOC102555694

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
G-protein coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor binding TAS
Traceable Author Statement
more info
PubMed 
hormone activity IEA
Inferred from Electronic Annotation
more info
 
neuropeptide Y receptor activity TAS
Traceable Author Statement
more info
PubMed 
neuropeptide Y receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
adult feeding behavior IDA
Inferred from Direct Assay
more info
PubMed 
central nervous system neuron development ISO
Inferred from Sequence Orthology
more info
 
cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
feeding behavior NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
neuropeptide signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of appetite IDA
Inferred from Direct Assay
more info
PubMed 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
sensory perception of taste IEP
Inferred from Expression Pattern
more info
PubMed 
synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
pro-neuropeptide Y
Names
pro-neuropeptide Y

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012614.2NP_036746.1  pro-neuropeptide Y preproprotein

    See proteins identical to NP_036746.1

    Status: REVIEWED

    Source sequence(s)
    AABR06030945, M20373
    UniProtKB/TrEMBL
    F2W8A6
    UniProtKB/Swiss-Prot
    P07808
    Related
    ENSRNOP00000013146, ENSRNOT00000013145
    Conserved Domains (1) summary
    cd00126
    Location:3065
    Blast Score: 163
    PAH; Pancreatic Hormone domain, a regulator of pancreatic and gastrointestinal functions; neuropeptide Y (NPY)b, peptide YY (PYY), and pancreatic polypetide (PP) are closely related; propeptide is enzymatically cleaved to yield the mature active peptide with ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

  1. NC_005103.3 

    Range
    144233753..144240956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000072.1 

    Range
    73795148..73802371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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