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    Npy neuropeptide Y [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24604, updated on 23-Dec-2015
    Official Symbol
    Npyprovided by RGD
    Official Full Name
    neuropeptide Yprovided by RGD
    Primary source
    RGD:3197
    See related
    Ensembl:ENSRNOG00000009768
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NPY02; RATNPY; RATNPY02
    Summary
    This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. Studies in the rat model of depression (Flinders Sensitive Line) show that this gene is downregulated in the hippocampus and the prefrontal cortex compared to the control ((Flinders Resistant Line). Alternatively spliced transcript variants of this gene have been described, but the function of all the variants is not known. [provided by RefSeq, Jul 2012]
    See Npy in MapViewer
    Location:
    4q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (79557856..79565059)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (144233753..144240956)

    Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene RGD1564712 Neighboring gene uncharacterized LOC102555544 Neighboring gene pro-neuropeptide Y-like Neighboring gene uncharacterized LOC102555694

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    G-protein coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    G-protein coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    neuropeptide Y receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    adult feeding behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    antibacterial humoral response ISO
    Inferred from Sequence Orthology
    more info
     
    antifungal humoral response ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    central nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    digestion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    monocyte activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of acute inflammatory response to antigenic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neuropeptide signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of appetite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of dopamine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of eating behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of nitric oxide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of nerve growth factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to yeast ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of taste IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    short-day photoperiodism IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012614.2NP_036746.1  pro-neuropeptide Y preproprotein

      See identical proteins and their annotated locations for NP_036746.1

      Status: REVIEWED

      Source sequence(s)
      AABR07060549, M20373
      UniProtKB/TrEMBL
      F2W8A6
      UniProtKB/Swiss-Prot
      P07808
      Related
      ENSRNOP00000013146, ENSRNOT00000013145
      Conserved Domains (1) summary
      cd00126
      Location:3065
      PAH; Pancreatic Hormone domain, a regulator of pancreatic and gastrointestinal functions; neuropeptide Y (NPY)b, peptide YY (PYY), and pancreatic polypetide (PP) are closely related; propeptide is enzymatically cleaved to yield the mature active peptide with ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

      Range
      79557856..79565059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000072.1 Alternate Rn_Celera

      Range
      73795148..73802371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)