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SHH sonic hedgehog [ Gallus gallus (chicken) ]

Gene ID: 395615, updated on 13-Sep-2014
Symbol
SHHprovided by CGNC
Full Name
sonic hedgehogprovided by CGNC
Primary source
CGNC:49404
See related
Ensembl:ENSGALG00000006379
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Testudines + Archosauria group; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus
See SHH in MapViewer
Location:
chromosome: 2
Exon count:
3
Annotation release Status Assembly Chr Location
102 current Gallus_gallus-4.0 (GCF_000002315.3) 2 NC_006089.3 (8080099..8089853, complement)

Chromosome 2 - NC_006089.3Genomic Context describing neighboring genes Neighboring gene engrailed homeobox 2 Neighboring gene RNA binding motif protein 33 Neighboring gene uncharacterized LOC101747467 Neighboring gene ring finger protein 32

Genomic Sequence:
NC_006089.3 chromosome 2 reference Gallus_gallus-4.0 Primary Assembly

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Hedgehog Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Hedgehog Signaling Pathway, organism-specific biosystemThe Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, pre...
  • Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
    Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
  • Hedgehog signaling pathway, conserved biosystem (from KEGG)
    Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
morphogen activity NAS
Non-traceable Author Statement
more info
PubMed 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
anterior/posterior pattern specification IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
cell fate determination NAS
Non-traceable Author Statement
more info
PubMed 
cell fate specification involved in pattern specification TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling IEA
Inferred from Electronic Annotation
more info
 
embryonic digit morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic limb morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
homeostasis of number of retina cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
intein-mediated protein splicing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
optic cup formation involved in camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
optic nerve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
polarity specification of anterior/posterior axis ISS
Inferred from Sequence or Structural Similarity
more info
 
polarity specification of dorsal/ventral axis NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of neural retina development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptosis involved in tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell differentiation involved in tissue homeostasis TAS
Traceable Author Statement
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
retinal pigment epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
sonic hedgehog protein
Names
sonic hedgehog protein
sonic hedgehog homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204821.1NP_990152.1  sonic hedgehog protein precursor

    See proteins identical to NP_990152.1

    Status: PROVISIONAL

    Source sequence(s)
    L28099
    UniProtKB/Swiss-Prot
    Q91035
    Related
    ENSGALP00000010292, ENSGALT00000010306
    Conserved Domains (3) summary
    cd00081
    Location:201352
    Blast Score: 282
    Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
    pfam01079
    Location:190411
    Blast Score: 851
    Hint; Hint module
    pfam01085
    Location:42187
    Blast Score: 843
    HH_signal; Hedgehog amino-terminal signalling domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 102

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Gallus_gallus-4.0 Primary Assembly

Genomic

  1. NC_006089.3 

    Range
    8080099..8089853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)