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    PIM3 Pim-3 proto-oncogene, serine/threonine kinase [ Homo sapiens (human) ]

    Gene ID: 415116, updated on 4-Sep-2016
    Official Symbol
    PIM3provided by HGNC
    Official Full Name
    Pim-3 proto-oncogene, serine/threonine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:19310
    See related
    Ensembl:ENSG00000198355 HPRD:15137; MIM:610580; Vega:OTTHUMG00000150290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    pim-3
    Summary
    The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]
    Orthologs
    Location:
    22q13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 22 NC_000022.11 (49960495..49964072)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50354143..50357720)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene zinc finger BED-type containing 4 Neighboring gene ALG12, alpha-1,6-mannosyltransferase Neighboring gene uncharacterized LOC107985553 Neighboring gene cysteine rich with EGF like domains 2 Neighboring gene microRNA 6821 Neighboring gene interleukin 17 receptor E like Neighboring gene tubulin tyrosine ligase like 8

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study of DSM-IV cannabis dependence.
    NHGRI GWA Catalog
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    NHGRI GWA Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of insulin secretion involved in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    serine/threonine-protein kinase pim-3
    Names
    pim-3 oncogene
    serine/threonine kinase Pim-3
    NP_001001852.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001852.3NP_001001852.2  serine/threonine-protein kinase pim-3

      See identical proteins and their annotated locations for NP_001001852.2

      Status: VALIDATED

      Source sequence(s)
      AB114795, CR536608, CT000425, DB482257
      Consensus CDS
      CCDS33678.1
      UniProtKB/Swiss-Prot
      Q86V86
      Related
      ENSP00000353824, OTTHUMP00000196970, ENST00000360612, OTTHUMT00000317406
      Conserved Domains (2) summary
      pfam00069
      Location:40293
      Pkinase; Protein kinase domain
      cl21453
      Location:39293
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p7 Primary Assembly

      Range
      49960495..49964072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018933.2 Alternate CHM1_1.1

      Range
      50312881..50316458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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