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AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase [ Homo sapiens (human) ]

Gene ID: 267, updated on 17-Mar-2015
Official Symbol
AMFRprovided by HGNC
Official Full Name
autocrine motility factor receptor, E3 ubiquitin protein ligaseprovided by HGNC
Primary source
HGNC:HGNC:463
See related
Ensembl:ENSG00000159461; HPRD:09130; MIM:603243; Vega:OTTHUMG00000133239
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP78; RNF45
Summary
This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]
Orthologs
See AMFR in MapViewer
Location:
16q21
Exon count:
16
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (56361452..56425538, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56395364..56459450, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O Neighboring gene uncharacterized LOC105371282 Neighboring gene uncharacterized LOC102723466 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 21 Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 1 Neighboring gene Bardet-Biedl syndrome 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • SREBP signalling, organism-specific biosystem (from WikiPathways)
    SREBP signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ER-associated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ER-associated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning or memory IEA
Inferred from Electronic Annotation
more info
 
movement of cell or subcellular component TAS
Traceable Author Statement
more info
PubMed 
protein oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Hrd1p ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
growth cone IEA
Inferred from Electronic Annotation
more info
 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
E3 ubiquitin-protein ligase AMFR
Names
E3 ubiquitin-protein ligase AMFR
RING finger protein 45
NP_001135.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144.5NP_001135.3  E3 ubiquitin-protein ligase AMFR

    See proteins identical to NP_001135.3

    Status: REVIEWED

    Source sequence(s)
    AA767223, AC009102, BC069197, BX345849, BX409690, CA748782
    Consensus CDS
    CCDS10758.1
    UniProtKB/Swiss-Prot
    Q9UKV5
    Related
    ENSP00000290649, OTTHUMP00000164316, ENST00000290649, OTTHUMT00000256978
    Conserved Domains (3) summary
    smart00546
    Location:456497
    CUE; Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs)
    COG5243
    Location:86382
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:340382
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    56361452..56425538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255889.2XP_005255946.1  

    See proteins identical to XP_005255946.1

    UniProtKB/TrEMBL
    A0A024R6R5
    Conserved Domains (3) summary
    smart00546
    Location:361402
    CUE; Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs)
    COG5243
    Location:2287
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:245287
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  2. XM_005255890.2XP_005255947.1  

    See proteins identical to XP_005255947.1

    UniProtKB/TrEMBL
    A0A024R6R5
    Conserved Domains (3) summary
    smart00546
    Location:361402
    CUE; Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs)
    COG5243
    Location:2287
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:245287
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    57802735..57866433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138958.1: Suppressed sequence

    Description
    NM_138958.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.