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    Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81683, updated on 11-Sep-2016
    Official Symbol
    Mifprovided by RGD
    Official Full Name
    macrophage migration inhibitory factor (glycosylation-inhibiting factor)provided by RGD
    Primary source
    RGD:621163
    See related
    Ensembl:ENSRNOG00000006589
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Summary
    inhibits random migration of macrophages and is involved in the pathogenesis of several inflammatory diseases [RGD, Feb 2006]
    Orthologs
    Location:
    20p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13715219..13732980)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (15885248..15886113)

    Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 11 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Neighboring gene derlin 3 Neighboring gene uncharacterized LOC103690388 Neighboring gene glutathione S-transferase, theta 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC72801

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    dopachrome isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    dopachrome isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phenylpyruvate tautomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phenylpyruvate tautomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    brain development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    brain renin-angiotensin system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    carboxylic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell aging ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    drinking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell aging ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mature B cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myeloid cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of acute inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of arachidonic acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of myeloid leukocyte cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of prostaglandin secretion involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotrimerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to heat IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to inorganic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to menaquinone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to progesterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to vitamin E IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    skin development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    wound healing IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    macrophage migration inhibitory factor
    Names
    L-dopachrome isomerase
    L-dopachrome tautomerase
    glutathione-binding 13 kDa protein
    phenylpyruvate tautomerase
    NP_112313.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031051.1NP_112313.1  macrophage migration inhibitory factor

      See identical proteins and their annotated locations for NP_112313.1

      Status: PROVISIONAL

      Source sequence(s)
      U62326
      UniProtKB/Swiss-Prot
      P30904
      UniProtKB/TrEMBL
      A0A0F7RQL3
      Related
      ENSRNOP00000008608, ENSRNOT00000008608
      Conserved Domains (1) summary
      pfam01187
      Location:2115
      MIF; Macrophage migration inhibitory factor (MIF)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

      Range
      13715219..13732980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601782.1XP_017457271.1  

      Conserved Domains (1) summary
      pfam01187
      Location:2115
      MIF; Macrophage migration inhibitory factor (MIF)

    Alternate Rn_Celera

    Genomic

    1. AC_000088.1 Alternate Rn_Celera

      Range
      14283080..14283945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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