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    Prkcq protein kinase C, theta [ Mus musculus (house mouse) ]

    Gene ID: 18761, updated on 7-Feb-2016
    Official Symbol
    Prkcqprovided by MGI
    Official Full Name
    protein kinase C, thetaprovided by MGI
    Primary source
    MGI:MGI:97601
    See related
    Ensembl:ENSMUSG00000026778; Vega:OTTMUSG00000011317
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pkcq; PKC-0; AW494342; PKCtheta; PKC-theta; A130035A12Rik
    Orthologs
    See Prkcq in Epigenomics, MapViewer
    Location:
    2 A1; 2 8.42 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (11172382..11301226)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (11094009..11222853)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene zinc finger and BTB domain containing 2 pseudogene Neighboring gene RIKEN cDNA 8030442B05 gene Neighboring gene predicted gene, 31902 Neighboring gene predicted gene 13293

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of T cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T-helper 17 type immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T-helper 2 cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-17 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-2 biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-4 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    protein kinase C theta type
    Names
    PKC theta
    nPKC-theta
    NP_032885.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008859.2NP_032885.1  protein kinase C theta type

      See identical proteins and their annotated locations for NP_032885.1

      Status: PROVISIONAL

      Source sequence(s)
      AL928715, AL929020
      Consensus CDS
      CCDS15682.1
      UniProtKB/TrEMBL
      A6H667
      UniProtKB/Swiss-Prot
      Q02111
      Related
      ENSMUSP00000028118, OTTMUSP00000012133, ENSMUST00000028118, OTTMUST00000026520
      Conserved Domains (3) summary
      smart00220
      Location:380634
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:232281
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05619
      Location:374704
      STKc_nPKC_theta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

      Range
      11172382..11301226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497398.2XP_006497461.1  

      Conserved Domains (3) summary
      smart00220
      Location:337591
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:189238
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05619
      Location:331661
      STKc_nPKC_theta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta
    2. XM_011238965.1XP_011237267.1  

      Conserved Domains (3) summary
      smart00220
      Location:265519
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:117166
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05619
      Location:259589
      STKc_nPKC_theta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta
    3. XM_006497399.1XP_006497462.1  

      See identical proteins and their annotated locations for XP_006497462.1

      UniProtKB/TrEMBL
      Q920N8
      Conserved Domains (2) summary
      smart00220
      Location:137391
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05619
      Location:131461
      STKc_nPKC_theta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta

    Alternate Mm_Celera

    Genomic

    1. AC_000024.1 Alternate Mm_Celera

      Range
      11093754..11222740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)