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    Chek1 checkpoint kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 12649, updated on 3-Apr-2016
    Official Symbol
    Chek1provided by MGI
    Official Full Name
    checkpoint kinase 1provided by MGI
    Primary source
    MGI:MGI:1202065
    See related
    Ensembl:ENSMUSG00000032113 Vega:OTTMUSG00000037031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Chk1; rad27; C85740
    Orthologs
    Location:
    9; 9 A5.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (36708482..36726658, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (36516067..36534243, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700027I24 gene Neighboring gene acrosomal vesicle protein 1 Neighboring gene STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) Neighboring gene predicted gene, 26787 Neighboring gene etoposide induced 2.4 mRNA

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
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    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle signaling pathway, organism-specific biosystem (from LIPID MAPS)
      Cell cycle signaling pathway, organism-specific biosystem
      Cell cycle signaling pathway
    • DNA damage-induced cell cycle checkpoints, organism-specific biosystem (from KEGG)
      DNA damage-induced cell cycle checkpoints, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • DNA damage-induced cell cycle checkpoints, conserved biosystem (from KEGG)
      DNA damage-induced cell cycle checkpoints, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • miRNA regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
      miRNA regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone kinase activity (H3-T11 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone kinase activity (H3-T11 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA damage checkpoint IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    DNA damage induced protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    G2 DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin-mediated maintenance of transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3-T11 phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of histone H3-K9 acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of mitotic centrosome separation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    replication fork IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    serine/threonine-protein kinase Chk1
    Names
    CHK1 checkpoint homolog
    checkpoint kinase 1 homolog
    checkpoint kinase-1
    rad27 homolog
    NP_031717.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007691.5NP_031717.2  serine/threonine-protein kinase Chk1

      See identical proteins and their annotated locations for NP_031717.2

      Status: VALIDATED

      Source sequence(s)
      AK033179, AK045336, AK166675
      Consensus CDS
      CCDS22972.1
      UniProtKB/Swiss-Prot
      O35280
      Related
      ENSMUSP00000034625, ENSMUST00000034625
      Conserved Domains (2) summary
      smart00220
      Location:9264
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14069
      Location:7265
      STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

      Range
      36708482..36726658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000031.1 Alternate Mm_Celera

      Range
      33911337..33929618 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)