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Npc1l1 NPC1-like 1 [ Mus musculus (house mouse) ]

Gene ID: 237636, updated on 8-Dec-2014
Official Symbol
Npc1l1provided by MGI
Official Full Name
NPC1-like 1provided by MGI
Primary source
MGI:MGI:2685089
Locus tag
RP23-198N14.2
See related
Ensembl:ENSMUSG00000020447; Vega:OTTMUSG00000000776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm243; 9130221N23Rik
See Npc1l1 in Epigenomics, MapViewer
Location:
11 A1; 11
Exon count:
20
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 11 NC_000077.6 (6211011..6230245, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase II, beta Neighboring gene NudC domain containing 3 Neighboring gene ribosomal protein S15A, pseudogene 6 Neighboring gene predicted gene, 35949 Neighboring gene predicted gene 11401

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Rab GTPase binding ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
hedgehog receptor activity IEA
Inferred from Electronic Annotation
more info
 
myosin V binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
intestinal cholesterol absorption ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
brush border membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
Niemann-Pick C1-like protein 1
Names
Niemann-Pick C1-like protein 1
Niemann-Pick disease, type C1
Niemann-Pick disease, type C1-like 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207242.2NP_997125.2  Niemann-Pick C1-like protein 1 precursor

    See proteins identical to NP_997125.2

    Status: VALIDATED

    Source sequence(s)
    AV377091, BB872216, BC131788, CJ191424
    Consensus CDS
    CCDS24413.1
    UniProtKB/TrEMBL
    A3KMG9
    UniProtKB/TrEMBL
    Z4YJC9
    Related
    ENSMUSP00000004505, OTTMUSP00000000725, ENSMUST00000004505, OTTMUST00000001518
    Conserved Domains (2) summary
    TIGR00917
    Location:321267
    2A060601; Niemann-Pick C type protein family
    pfam12349
    Location:684815
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000077.6 

    Range
    6211011..6230245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514693.1XP_006514756.1  

    Conserved Domains (2) summary
    TIGR00917
    Location:32938
    2A060601; Niemann-Pick C type protein family
    pfam12349
    Location:684815
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation

Alternate Mm_Celera

Genomic

  1. AC_000033.1 

    Range
    6693602..6712842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)