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    Tyr tyrosinase [ Mus musculus (house mouse) ]

    Gene ID: 22173, updated on 27-Jun-2015
    Official Symbol
    Tyrprovided by MGI
    Official Full Name
    tyrosinaseprovided by MGI
    Primary source
    MGI:MGI:98880
    See related
    Ensembl:ENSMUSG00000004651
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    c; Oca1; skc35; albino
    Orthologs
    Location:
    7 D3-E1; 7 49.01 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (87425276..87493442, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (94575915..94641921, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4, X-linked pseudogene Neighboring gene NADPH oxidase 4 Neighboring gene glutamate receptor, metabotropic 5 Neighboring gene splicing factor 3a, subunit 1 pseudogene Neighboring gene cathepsin C

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    monophenol monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    monophenol monooxygenase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    melanin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    melanin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process TAS
    Traceable Author Statement
    more info
    PubMed 
    pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pigmentation ISO
    Inferred from Sequence Orthology
    more info
     
    thymus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    melanosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with melanosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    tyrosinase
    Names
    tyrosinase
    albino locus protein
    monophenol monooxygenase
    NP_035791.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011661.4NP_035791.1  tyrosinase precursor

      See identical proteins and their annotated locations for NP_035791.1

      Status: PROVISIONAL

      Source sequence(s)
      AC122517, AC141329
      Consensus CDS
      CCDS52304.1
      UniProtKB/Swiss-Prot
      P11344
      UniProtKB/TrEMBL
      Q91XK0
      Related
      ENSMUSP00000004770, ENSMUST00000004770
      Conserved Domains (1) summary
      pfam00264
      Location:171403
      Tyrosinase; Common central domain of tyrosinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

      Range
      87425276..87493442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507576.1XP_006507639.1  

      Conserved Domains (1) summary
      pfam00264
      Location:120352
      Tyrosinase; Common central domain of tyrosinase
    2. XM_006507578.1XP_006507641.1  

      See identical proteins and their annotated locations for XP_006507641.1

      Conserved Domains (1) summary
      pfam00264
      Location:171345
      Tyrosinase; Common central domain of tyrosinase
    3. XM_006507577.1XP_006507640.1  

      Conserved Domains (1) summary
      pfam00264
      Location:171396
      Tyrosinase; Common central domain of tyrosinase

    Alternate Mm_Celera

    Genomic

    1. AC_000029.1 Alternate Mm_Celera

      Range
      84786868..84854808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)