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CDCP1 CUB domain containing protein 1 [ Homo sapiens (human) ]

Gene ID: 64866, updated on 21-Oct-2014
Official Symbol
CDCP1provided by HGNC
Official Full Name
CUB domain containing protein 1provided by HGNC
Primary source
HGNC:HGNC:24357
Locus tag
UNQ2486/PRO5773
See related
Ensembl:ENSG00000163814; HPRD:16696; MIM:611735; Vega:OTTHUMG00000133090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD318; TRASK; SIMA135
Summary
This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
See CDCP1 in Epigenomics, MapViewer
Location:
3p21.31
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (45082274..45146422, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (45123766..45187914, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene exosome component 7 Neighboring gene C-type lectin domain family 3, member B Neighboring gene RNA, U5B small nuclear 3, pseudogene Neighboring gene ribosomal protein S24 pseudogene 8 Neighboring gene uncharacterized LOC101928636

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
CUB domain-containing protein 1
Names
CUB domain-containing protein 1
membrane glycoprotein gp140
transmembrane and associated with src kinases
subtractive immunization M plus HEp3-associated 135 kDa protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022842.4NP_073753.3  CUB domain-containing protein 1 isoform 1 precursor

    See proteins identical to NP_073753.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AY026461, AY167484, BC021099, CD367582
    Consensus CDS
    CCDS2727.1
    UniProtKB/Swiss-Prot
    Q9H5V8
    Related
    ENSP00000296129, OTTHUMP00000164120, ENST00000296129, OTTHUMT00000256748
    Conserved Domains (1) summary
    cl00049
    Location:225297
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  2. NM_178181.2NP_835488.1  CUB domain-containing protein 1 isoform 2 precursor

    See proteins identical to NP_835488.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) transcribes past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AY358779, BC021099
    Consensus CDS
    CCDS46812.1
    UniProtKB/Swiss-Prot
    Q9H5V8
    Related
    ENSP00000399342, OTTHUMP00000209568, ENST00000425231, OTTHUMT00000343581
    Conserved Domains (1) summary
    cl00049
    Location:225297
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    45082274..45146422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265404.1XP_005265461.1  

    Conserved Domains (1) summary
    cl00049
    Location:159231
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    45167190..45231748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    45073764..45137892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)