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    Scn3a sodium voltage-gated channel alpha subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497770, updated on 13-Jun-2016
    Official Symbol
    Scn3aprovided by RGD
    Official Full Name
    sodium voltage-gated channel alpha subunit 3provided by RGD
    Primary source
    RGD:3635
    See related
    Ensembl:ENSRNOG00000005007
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SCIII; Scn2a; Nav1.3
    Summary
    may play a role in neuronal hyperexcitability and neuropathic pain in response to spinal cord injury [RGD, Feb 2006]
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    Location:
    3q21
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (51530897..51643140, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (58165763..58277870, complement)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene cordon-bleu WH2 repeat protein-like 1 Neighboring gene solute carrier family 38, member 11 Neighboring gene uncharacterized LOC102553383 Neighboring gene sodium voltage-gated channel alpha subunit 2 Neighboring gene cysteine and serine rich nuclear protein 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Taste transduction, organism-specific biosystem (from KEGG)
      Taste transduction, organism-specific biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
    • Taste transduction, conserved biosystem (from KEGG)
      Taste transduction, conserved biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sodium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated sodium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated sodium channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to antibiotic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane depolarization during action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nervous system development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    neuronal action potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    response to pyrethroid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to wounding IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated sodium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated sodium channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated sodium channel complex TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    sodium channel protein type 3 subunit alpha
    Names
    sodium channel protein brain III subunit alpha
    sodium channel protein type 3 subunit alpha-like
    sodium channel protein type III subunit alpha
    sodium channel protein, brain III subunit alpha
    sodium channel, voltage-gated, type 3, alpha subunit
    sodium channel, voltage-gated, type III, alpha subunit
    voltage-gated sodium channel subtype III
    voltage-gated sodium channel subunit alpha Nav1.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013119.1NP_037251.1  sodium channel protein type 3 subunit alpha

      See identical proteins and their annotated locations for NP_037251.1

      Status: PROVISIONAL

      Source sequence(s)
      Y00766
      UniProtKB/Swiss-Prot
      P08104
      Related
      ENSRNOP00000006646, ENSRNOT00000006646
      Conserved Domains (5) summary
      cd13433
      Location:14201472
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:11931418
      Ion_trans; Ion transport protein
      pfam06512
      Location:9491167
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:496662
      DUF3451; Domain of unknown function (DUF3451)
      cl16916
      Location:16591694
      ChtBD1; Hevein or type 1 chitin binding domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      51530897..51643140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761915.1XP_008760137.1  

      See identical proteins and their annotated locations for XP_008760137.1

      Conserved Domains (5) summary
      cd13433
      Location:14521504
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:12251450
      Ion_trans; Ion transport protein
      pfam06512
      Location:9811199
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:496694
      DUF3451; Domain of unknown function (DUF3451)
      cl16916
      Location:16911726
      ChtBD1; Hevein or type 1 chitin binding domain
    2. XM_008761916.1XP_008760138.1  

      Conserved Domains (5) summary
      cd13433
      Location:14521504
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:12251450
      Ion_trans; Ion transport protein
      pfam06512
      Location:9811199
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:496694
      DUF3451; Domain of unknown function (DUF3451)
      cl16916
      Location:16911726
      ChtBD1; Hevein or type 1 chitin binding domain
    3. XM_008761919.1XP_008760141.1  

      UniProtKB/TrEMBL
      F1LX08
      Related
      ENSRNOP00000072091, ENSRNOT00000081401
      Conserved Domains (5) summary
      cd13433
      Location:14201472
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:11931418
      Ion_trans; Ion transport protein
      pfam06512
      Location:9491167
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:496662
      DUF3451; Domain of unknown function (DUF3451)
      cl16916
      Location:16591694
      ChtBD1; Hevein or type 1 chitin binding domain
    4. XM_008761918.1XP_008760140.1  

      Conserved Domains (5) summary
      cd13433
      Location:14231475
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:11961421
      Ion_trans; Ion transport protein
      pfam06512
      Location:9521170
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:496665
      DUF3451; Domain of unknown function (DUF3451)
      cl16916
      Location:16621697
      ChtBD1; Hevein or type 1 chitin binding domain
    5. XM_008761917.1XP_008760139.1  

      See identical proteins and their annotated locations for XP_008760139.1

      Conserved Domains (5) summary
      cd13433
      Location:14521504
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:12251450
      Ion_trans; Ion transport protein
      pfam06512
      Location:9811199
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:496694
      DUF3451; Domain of unknown function (DUF3451)
      cl16916
      Location:16911726
      ChtBD1; Hevein or type 1 chitin binding domain
    6. XM_008761914.1XP_008760136.1  

      See identical proteins and their annotated locations for XP_008760136.1

      Conserved Domains (5) summary
      cd13433
      Location:14521504
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:12251450
      Ion_trans; Ion transport protein
      pfam06512
      Location:9811199
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:496694
      DUF3451; Domain of unknown function (DUF3451)
      cl16916
      Location:16911726
      ChtBD1; Hevein or type 1 chitin binding domain
    7. XM_008761920.1XP_008760142.1  

      Conserved Domains (5) summary
      cd13433
      Location:14201472
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:11931418
      Ion_trans; Ion transport protein
      pfam06512
      Location:9491167
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:496662
      DUF3451; Domain of unknown function (DUF3451)
      cl16916
      Location:16591694
      ChtBD1; Hevein or type 1 chitin binding domain

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      49742093..49851946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)