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Egf epidermal growth factor [ Mus musculus (house mouse) ]

Gene ID: 13645, updated on 19-May-2015
Official Symbol
Egfprovided by MGI
Official Full Name
epidermal growth factorprovided by MGI
Primary source
MGI:MGI:95290
See related
Ensembl:ENSMUSG00000028017
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI790464
Orthologs
See Egf in MapViewer
Location:
3 G3; 3 58.5 cM
Exon count:
25
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (129677569..129755322, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (129380493..129458240, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A, pseudogene 7 Neighboring gene predicted gene, 35986 Neighboring gene ELOVL family member 6, elongation of long chain fatty acids (yeast) Neighboring gene RIKEN cDNA 6330410L21 gene Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 Neighboring gene predicted gene, 36130 Neighboring gene retinal pigment epithelium derived rhodopsin homolog Neighboring gene GAR1 ribonucleoprotein homolog (yeast)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
STAT protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPKK activity IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
branching morphogenesis of an epithelial tube IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
mammary gland alveolus development IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of secretion ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catenin import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cerebellar granule cell precursor proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of protein transport ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
pro-epidermal growth factor
Names
pro-epidermal growth factor
Pro-epidermal growth factor precursor (EGF)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010113.3NP_034243.2  pro-epidermal growth factor precursor

    See identical proteins and their annotated locations for NP_034243.2

    Status: VALIDATED

    Source sequence(s)
    AC098732
    Consensus CDS
    CCDS17833.1
    UniProtKB/Swiss-Prot
    P01132
    Related
    ENSMUSP00000029653, ENSMUST00000029653
    Conserved Domains (3) summary
    smart00135
    Location:596639
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00054
    Location:919947
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam14670
    Location:366401
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

    Range
    129677569..129755322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500991.1XP_006501054.1  

    Conserved Domains (3) summary
    smart00135
    Location:95138
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00054
    Location:418446
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam14670
    Location:250285
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  2. XM_011240011.1XP_011238313.1  

    Conserved Domains (3) summary
    smart00135
    Location:600643
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00054
    Location:881917
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam14670
    Location:370405
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  3. XM_011240010.1XP_011238312.1  

    Conserved Domains (3) summary
    smart00135
    Location:600643
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00054
    Location:923951
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam14670
    Location:370405
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  4. XM_006500990.2XP_006501053.1  

    Conserved Domains (3) summary
    smart00135
    Location:596639
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00054
    Location:877913
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam14670
    Location:366401
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RNA

  1. XR_867211.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000025.1 Alternate Mm_Celera

    Range
    136187440..136268006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)