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Enah enabled homolog (Drosophila) [ Mus musculus (house mouse) ]

Gene ID: 13800, updated on 13-Jul-2014
Official Symbol
Enahprovided by MGI
Official Full Name
enabled homolog (Drosophila)provided by MGI
Primary source
MGI:108360
See related
Ensembl:ENSMUSG00000022995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mena; WBP8; Ndpp1; NDPP-1
See Enah in Epigenomics, MapViewer
Location:
1 H5; 1 84.93 cM
Exon count:
19
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 1 NC_000067.6 (181904445..182019980, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 14 Neighboring gene uncharacterized LOC102636665 Neighboring gene lamin B receptor Neighboring gene nuclear encoded tRNA serine 15 (anticodon GCT) Neighboring gene uncharacterized LOC102636735

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
WW domain binding ISO
Inferred from Sequence Orthology
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
profilin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
actin filament organization IDA
Inferred from Direct Assay
more info
PubMed 
actin polymerization or depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular component movement IDA
Inferred from Direct Assay
more info
PubMed 
intracellular transport IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
filopodium IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein enabled homolog
Names
protein enabled homolog
NPC derived proline rich protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083120.2NP_001076589.1  protein enabled homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AC122204, AC165229
    Consensus CDS
    CCDS48473.1
    UniProtKB/TrEMBL
    E9QKR1
    Related
    ENSMUSP00000106653, ENSMUST00000111024
    Conserved Domains (2) summary
    pfam08776
    Location:745784
    Blast Score: 179
    VASP_tetra; VASP tetramerization domain
    cd01207
    Location:5112
    Blast Score: 602
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
  2. NM_001083121.2NP_001076590.1  protein enabled homolog isoform 4

    See proteins identical to NP_001076590.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1.
    Source sequence(s)
    AC122204, AC165229
    UniProtKB/Swiss-Prot
    Q03173
    Related
    ENSMUSP00000106654, ENSMUST00000111025
    Conserved Domains (2) summary
    pfam08776
    Location:501540
    Blast Score: 171
    VASP_tetra; VASP tetramerization domain
    cd01207
    Location:5112
    Blast Score: 602
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
  3. NM_008680.3NP_032706.2  protein enabled homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and contains an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC122204, AC165229
    Consensus CDS
    CCDS48474.1
    UniProtKB/TrEMBL
    E9QKQ9
    Related
    ENSMUSP00000106659, ENSMUST00000111030
    Conserved Domains (2) summary
    pfam08776
    Location:749788
    Blast Score: 179
    VASP_tetra; VASP tetramerization domain
    cd01207
    Location:5112
    Blast Score: 602
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
  4. NM_010135.3NP_034265.2  protein enabled homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC122204, AC165229
    Consensus CDS
    CCDS35811.1
    UniProtKB/TrEMBL
    E9QLZ9
    Related
    ENSMUSP00000077781, ENSMUST00000078719
    Conserved Domains (2) summary
    pfam08776
    Location:764803
    Blast Score: 179
    VASP_tetra; VASP tetramerization domain
    cd01207
    Location:5112
    Blast Score: 602
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000067.6 

    Range
    181904445..182019980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496647.1XP_006496710.1  

    Conserved Domains (2) summary
    pfam08776
    Location:766805
    Blast Score: 179
    VASP_tetra; VASP tetramerization domain
    cd01207
    Location:5112
    Blast Score: 602
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
  2. XM_006496644.1XP_006496707.1  

    Conserved Domains (2) summary
    pfam08776
    Location:789828
    Blast Score: 179
    VASP_tetra; VASP tetramerization domain
    cd01207
    Location:5112
    Blast Score: 602
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
  3. XM_006496652.1XP_006496715.1  

    Conserved Domains (2) summary
    pfam08776
    Location:495534
    Blast Score: 172
    VASP_tetra; VASP tetramerization domain
    cd01207
    Location:36143
    Blast Score: 602
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
  4. XM_006496651.1XP_006496714.1  

    Conserved Domains (2) summary
    pfam08776
    Location:532571
    Blast Score: 175
    VASP_tetra; VASP tetramerization domain
    cd01207
    Location:36143
    Blast Score: 602
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
  5. XM_006496650.1XP_006496713.1  

    Conserved Domains (2) summary
    pfam08776
    Location:553592
    Blast Score: 174
    VASP_tetra; VASP tetramerization domain
    cd01207
    Location:36143
    Blast Score: 602
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
  6. XM_006496646.1XP_006496709.1  

    Conserved Domains (2) summary
    pfam08776
    Location:776815
    Blast Score: 179
    VASP_tetra; VASP tetramerization domain
    cd01207
    Location:36143
    Blast Score: 602
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
  7. XM_006496645.1XP_006496708.1  

    Conserved Domains (2) summary
    pfam08776
    Location:780819
    Blast Score: 179
    VASP_tetra; VASP tetramerization domain
    cd01207
    Location:36143
    Blast Score: 602
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
  8. XM_006496643.1XP_006496706.1  

    Conserved Domains (2) summary
    pfam08776
    Location:795834
    Blast Score: 179
    VASP_tetra; VASP tetramerization domain
    cd01207
    Location:36143
    Blast Score: 602
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
  9. XM_006496649.1XP_006496712.1  

    Conserved Domains (1) summary
    pfam08776
    Location:691730
    Blast Score: 179
    VASP_tetra; VASP tetramerization domain
  10. XM_006496648.1XP_006496711.1  

    Conserved Domains (1) summary
    pfam08776
    Location:695734
    Blast Score: 179
    VASP_tetra; VASP tetramerization domain

Alternate Mm_Celera

Genomic

  1. AC_000023.1 

    Range
    188957160..189017504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)