Display Settings:

Format

Send to:

Choose Destination

Tph1 tryptophan hydroxylase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24848, updated on 13-Jan-2015
Official Symbol
Tph1provided by RGD
Official Full Name
tryptophan hydroxylase 1provided by RGD
Primary source
RGD:3895
See related
Ensembl:ENSRNOG00000011672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Tph
Summary
catalyzes the conversion of l-tryptophan to 5-hydroxy-l-tryptophan; member of pterin-dependent aromatic amino acid hydroxylase family [RGD, Feb 2006]
Orthologs
See Tph1 in MapViewer
Location:
1q22
Exon count:
13
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (102669868..102699442, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (103746878..103774100, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene potassium voltage gated channel, Shaw-related subfamily, member 1 Neighboring gene secretion regulating guanine nucleotide exchange factor Neighboring gene uncharacterized LOC103691115 Neighboring gene similar to Serum amyloid A-3 protein precursor Neighboring gene serum amyloid A-like 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
amino acid binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
tryptophan 5-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
tryptophan 5-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
bone remodeling IEA
Inferred from Electronic Annotation
more info
 
bone remodeling ISO
Inferred from Sequence Orthology
more info
 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
mammary gland alveolus development IEA
Inferred from Electronic Annotation
more info
 
mammary gland alveolus development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
response to immobilization stress IEP
Inferred from Expression Pattern
more info
PubMed 
serotonin biosynthetic process from tryptophan TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
tryptophan 5-hydroxylase 1
Names
tryptophan 5-hydroxylase 1
tryptophan 5-monooxygenase 1
NP_001094104.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100634.2NP_001094104.1  tryptophan 5-hydroxylase 1

    See proteins identical to NP_001094104.1

    Status: VALIDATED

    Source sequence(s)
    AABR07003260, AABR07003262
    UniProtKB/Swiss-Prot
    P09810
    Related
    ENSRNOP00000052959, ENSRNOT00000056109
    Conserved Domains (3) summary
    TIGR01270
    Location:3439
    Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
    cd04929
    Location:1991
    ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
    cd03346
    Location:106392
    eu_TrpOH; Eukaryotic tryptophan hydroxylase (TrpOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 

    Range
    102669868..102699442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229219.1XP_006229281.1  

    See proteins identical to XP_006229281.1

    UniProtKB/Swiss-Prot
    P09810
    Conserved Domains (3) summary
    TIGR01270
    Location:3439
    Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
    cd04929
    Location:1991
    ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
    cd03346
    Location:106392
    eu_TrpOH; Eukaryotic tryptophan hydroxylase (TrpOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic ...
  2. XM_006229218.2XP_006229280.1  

    Conserved Domains (3) summary
    TIGR01270
    Location:69505
    Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
    cd04929
    Location:85157
    ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
    cd03346
    Location:172458
    eu_TrpOH; Eukaryotic tryptophan hydroxylase (TrpOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic ...

Alternate Rn_Celera

Genomic

  1. AC_000069.1 

    Range
    91404769..91425505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)