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Egfr epidermal growth factor receptor [ Mus musculus (house mouse) ]

Gene ID: 13649, updated on 18-Dec-2014
Official Symbol
Egfrprovided by MGI
Official Full Name
epidermal growth factor receptorprovided by MGI
Primary source
MGI:MGI:95294
Locus tag
RP23-295E4.1
See related
Ensembl:ENSMUSG00000020122; Vega:OTTMUSG00000005185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wa5; wa2; Erbb; Errp; wa-2; Errb1; AI552599; 9030024J15Rik
See Egfr in Epigenomics, MapViewer
Location:
11 A1-A4; 11 9.41 cM
Exon count:
29
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 11 NC_000077.6 (16752203..16913907)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene ubiquitin-like domain containing CTD phosphatase 1 Neighboring gene predicted gene 12664 Neighboring gene Egfr long non-coding downstream RNA Neighboring gene F-box protein 48

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
epidermal growth factor binding ISO
Inferred from Sequence Orthology
more info
 
epidermal growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
glycoprotein binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
integrin binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to nitric-oxide synthase regulator activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
receptor signaling protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
signal transducer activity IDA
Inferred from Direct Assay
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of MAPKK activity ISO
Inferred from Sequence Orthology
more info
 
astrocyte activation ISO
Inferred from Sequence Orthology
more info
 
cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to estradiol stimulus ISO
Inferred from Sequence Orthology
more info
 
cerebral cortex cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
learning or memory ISO
Inferred from Sequence Orthology
more info
 
magnesium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
morphogenesis of an epithelial fold IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
ovulation cycle ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catenin import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasodilation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
response to UV-A ISO
Inferred from Sequence Orthology
more info
 
response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
single organismal cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
translation ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
endosome membrane ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
epidermal growth factor receptor
Names
epidermal growth factor receptor
waved 2
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
NP_031938.1
NP_997538.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007912.4NP_031938.1  epidermal growth factor receptor isoform 2 precursor

    See proteins identical to NP_031938.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK004883, AK004944
    Consensus CDS
    CCDS24444.1
    UniProtKB/TrEMBL
    Q9WVF5
    Related
    ENSMUSP00000099948, OTTMUSP00000005386, ENSMUST00000102884, OTTMUST00000011586
    Conserved Domains (4) summary
    cd00064
    Location:558598
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:184337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505636
    GF_recep_IV; Growth factor receptor domain IV
  2. NM_207655.2NP_997538.1  epidermal growth factor receptor isoform 1 precursor

    See proteins identical to NP_997538.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF275367, AK004883, AK163338, BQ553815, BY725722
    Consensus CDS
    CCDS24443.1
    UniProtKB/Swiss-Prot
    Q01279
    UniProtKB/TrEMBL
    Q3TQS6
    UniProtKB/TrEMBL
    Q9EP98
    UniProtKB/TrEMBL
    Q9WVF5
    Conserved Domains (7) summary
    cd05108
    Location:7061021
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cd12093
    Location:634679
    TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
    cd00064
    Location:558598
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:184337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57168
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:714970
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:505636
    GF_recep_IV; Growth factor receptor domain IV

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000077.6 

    Range
    16752203..16913907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514491.1XP_006514554.1  

    Conserved Domains (7) summary
    cd05108
    Location:653968
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cd12093
    Location:581626
    TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
    cd00064
    Location:505545
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:131284
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:4115
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:661917
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:452583
    GF_recep_IV; Growth factor receptor domain IV

Alternate Mm_Celera

Genomic

  1. AC_000033.1 

    Range
    17126474..17287898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)