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KCNK6 potassium channel, subfamily K, member 6 [ Homo sapiens (human) ]

Gene ID: 9424, updated on 7-Dec-2014
Official Symbol
KCNK6provided by HGNC
Official Full Name
potassium channel, subfamily K, member 6provided by HGNC
Primary source
HGNC:HGNC:6281
See related
Ensembl:ENSG00000099337; HPRD:06803; MIM:603939; Vega:OTTHUMG00000182325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOSS; KCNK8; TWIK2; K2p6.1; TWIK-2
Summary
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]
See KCNK6 in Epigenomics, MapViewer
Location:
19q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (38319831..38333427)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38810484..38819654)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene serine peptidase inhibitor, Kunitz type, 2 Neighboring gene chromosome 19 open reading frame 33 Neighboring gene Yip1 interacting factor homolog B (S. cerevisiae) Neighboring gene catsper channel auxiliary subunit gamma Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 8

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human potassium channel, subfamily K, member 6 (KCNK6) at amino acid residues 42-43 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK), organism-specific biosystem (from REACTOME)
    Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK), organism-specific biosystemTWIK channels exhibit very low current and comprise of TWIK1, TWIK2 and KCNK7 members. TWIK current may be low due to rapid recycling of the channels from the plasma membrane.
  • Tandem pore domain potassium channels, organism-specific biosystem (from REACTOME)
    Tandem pore domain potassium channels, organism-specific biosystemTandem pore domain K+ channels (K2p) produce leak K+ current which stabilizes negative membrane potential and counter balances depolarization. These channels are regulated by voltage independent mech...

Homology

Clone Names

  • FLJ12282

Gene Ontology Provided by GOA

Function Evidence Code Pubs
inward rectifier potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of resting membrane potential IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
potassium channel subfamily K member 6
Names
potassium channel subfamily K member 6
K2P6.1 potassium channel
TWIK-originated similarity sequence
TWIK-originated sodium similarity sequence
inward rectifying potassium channel protein TWIK-2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004823.1NP_004814.1  potassium channel subfamily K member 6

    See proteins identical to NP_004814.1

    Status: REVIEWED

    Source sequence(s)
    AF117708
    Consensus CDS
    CCDS12513.1
    UniProtKB/TrEMBL
    B2RDS2
    UniProtKB/Swiss-Prot
    Q9Y257
    Related
    ENSP00000263372, OTTHUMP00000268936, ENST00000263372, OTTHUMT00000460524
    Conserved Domains (1) summary
    pfam07885
    Location:91139
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    38319831..38333427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723508.1XP_006723571.1  

    Conserved Domains (1) summary
    pfam07885
    Location:91139
    Ion_trans_2; Ion channel
  2. XM_006723509.1XP_006723572.1  

    See proteins identical to XP_006723572.1

    UniProtKB/TrEMBL
    B2RDS2
    UniProtKB/Swiss-Prot
    Q9Y257
    Conserved Domains (1) summary
    pfam07885
    Location:91139
    Ion_trans_2; Ion channel
  3. XM_006723510.1XP_006723573.1  

    See proteins identical to XP_006723573.1

    UniProtKB/Swiss-Prot
    Q9Y257
    Conserved Domains (1) summary
    pfam07885
    Location:46122
    Ion_trans_2; Ion channel
  4. XM_005259431.2XP_005259488.1  

    See proteins identical to XP_005259488.1

    UniProtKB/Swiss-Prot
    Q9Y257
    Conserved Domains (1) summary
    pfam07885
    Location:46122
    Ion_trans_2; Ion channel

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    38810843..38820013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    35258112..35267183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)