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    Avpr1a arginine vasopressin receptor 1A [ Mus musculus (house mouse) ]

    Gene ID: 54140, updated on 4-Jul-2015
    Official Symbol
    Avpr1aprovided by MGI
    Official Full Name
    arginine vasopressin receptor 1Aprovided by MGI
    Primary source
    MGI:MGI:1859216
    See related
    Ensembl:ENSMUSG00000020123; Vega:OTTMUSG00000020920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    V1a; AVPR; V1aR; Avpr1
    Summary
    This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues [provided by RefSeq, Jul 2008]
    Orthologs
    See Avpr1a in Epigenomics, MapViewer
    Location:
    10; 10 D3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (122448499..122453453)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (121885555..121890509)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40790 Neighboring gene predicted gene, 36041 Neighboring gene predicted gene, 40791 Neighboring gene RIKEN cDNA A130077B15 gene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    V1A vasopressin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    vasopressin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    vasopressin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    grooming behavior ISO
    Inferred from Sequence Orthology
    more info
     
    maternal aggressive behavior ISO
    Inferred from Sequence Orthology
    more info
     
    maternal behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    maternal behavior ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of female receptivity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transmission of nerve impulse ISO
    Inferred from Sequence Orthology
    more info
     
    penile erection ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular pH reduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of renal sodium excretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasoconstriction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of systemic arterial blood pressure by vasopressin IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to inorganic substance ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    response to peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    social behavior ISO
    Inferred from Sequence Orthology
    more info
     
    sperm ejaculation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    vasopressin V1a receptor
    Names
    AVPR V1a
    V1a arginine vasopressin receptor
    antidiuretic hormone receptor 1a
    vascular/hepatic-type arginine vasopressin receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016847.2NP_058543.2  vasopressin V1a receptor

      See identical proteins and their annotated locations for NP_058543.2

      Status: REVIEWED

      Source sequence(s)
      D49730
      Consensus CDS
      CCDS24215.1
      UniProtKB/TrEMBL
      Q3U1H9
      UniProtKB/Swiss-Prot
      Q62463
      Related
      ENSMUSP00000020323, OTTMUSP00000022915, ENSMUST00000020323, OTTMUST00000049450
      Conserved Domains (3) summary
      pfam08983
      Location:377423
      DUF1856; Domain of unknown function (DUF1856)
      pfam00001
      Location:78353
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam10320
      Location:62259
      7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

      Range
      122448499..122453453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000032.1 Alternate Mm_Celera

      Range
      124830307..124835265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)