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Acads acyl-Coenzyme A dehydrogenase, short chain [ Mus musculus (house mouse) ]

Gene ID: 11409, updated on 17-Mar-2015
Official Symbol
Acadsprovided by MGI
Official Full Name
acyl-Coenzyme A dehydrogenase, short chainprovided by MGI
Primary source
MGI:MGI:87868
See related
Ensembl:ENSMUSG00000029545; Vega:OTTMUSG00000014625
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bcd1; SCAD; Bcd-1; Hdlq8; AI196007
Summary
This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the Acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum at C(four)-CoA. In mice, deficiency of this gene has been linked to cold sensitivity and increased high-density lipoprotein levels. [provided by RefSeq, Nov 2012]
Orthologs
See Acads in MapViewer
Location:
5 55.99 cM; 5 F
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (115110299..115119346, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (115560308..115569322, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35015 Neighboring gene signal peptide peptidase 3 Neighboring gene ribosomal protein L37, retrotransposed Neighboring gene unc-119 homolog B (C. elegans) Neighboring gene malectin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
HDL QTL 8
GeneReviews: Not available

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
butyryl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
fatty-acyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
butyrate catabolic process ISO
Inferred from Sequence Orthology
more info
 
fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
short-chain specific acyl-CoA dehydrogenase, mitochondrial
Names
short-chain specific acyl-CoA dehydrogenase, mitochondrial
butyryl-CoA dehydrogenase
NP_031409.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007383.3NP_031409.2  short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

    See proteins identical to NP_031409.2

    Status: REVIEWED

    Source sequence(s)
    AK169428, BE993251, BY077302
    Consensus CDS
    CCDS19579.1
    UniProtKB/Swiss-Prot
    Q07417
    Related
    ENSMUSP00000031524, OTTMUSP00000015526, ENSMUST00000031524, OTTMUST00000034682
    Conserved Domains (2) summary
    cd01158
    Location:36408
    SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases
    COG1960
    Location:33412
    CaiA; Acyl-CoA dehydrogenases [Lipid metabolism]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    115110299..115119346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    112206409..112215520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)