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    LEU3 leucine-responsive transcriptional regulator LEU3 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 851172, updated on 5-Jun-2016
    Gene symbol
    LEU3
    Gene description
    leucine-responsive transcriptional regulator LEU3
    Primary source
    SGD:S000004443
    Locus tag
    YLR451W
    Gene type
    protein coding
    RNA name
    leucine-responsive transcriptional regulator LEU3
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See LEU3 in Map Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1036093..1038753)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase FPR4 Neighboring gene hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 Neighboring gene GTPase-activating protein SST2 Neighboring gene Rif2p

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    leucine-responsive transcriptional regulator LEU3
    NP_013556.3
    • Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1036093..1038753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182339.3NP_013556.3  leucine-responsive transcriptional regulator LEU3 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_013556.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08638
      Conserved Domains (2) summary
      cd12148
      Location:201620
      fungal_TF_MHR; fungal transcription factor regulatory middle homology region
      cd00067
      Location:3268
      GAL4; GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations