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    Rb1 retinoblastoma 1 [ Mus musculus (house mouse) ]

    Gene ID: 19645, updated on 29-Jun-2016
    Official Symbol
    Rb1provided by MGI
    Official Full Name
    retinoblastoma 1provided by MGI
    Primary source
    MGI:MGI:97874
    See related
    Ensembl:ENSMUSG00000022105 Vega:OTTMUSG00000036132
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rb; pRb; Rb-1
    Orthologs
    Location:
    14 38.73 cM; 14 D3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (73194453..73325885, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (73595309..73725598, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35388 Neighboring gene regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 Neighboring gene microRNA 687 Neighboring gene lysophosphatidic acid receptor 6 Neighboring gene integral membrane protein 2B Neighboring gene predicted gene, 35450

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    core promoter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell morphogenesis involved in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enucleate erythrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    glial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hepatocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of hepatocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription involved in G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of macrophage differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein localization to chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cohesin loading ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of lipid kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    sister chromatid biorientation ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    striated muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    tissue homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PML body ISO
    Inferred from Sequence Orthology
    more info
     
    Rb-E2F complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cyclin/CDK positive transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    retinoblastoma-associated protein
    Names
    pp105

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009029.2NP_033055.2  retinoblastoma-associated protein

      See identical proteins and their annotated locations for NP_033055.2

      Status: PROVISIONAL

      Source sequence(s)
      BC096525
      Consensus CDS
      CCDS27267.1
      UniProtKB/Swiss-Prot
      P13405
      Related
      ENSMUSP00000022701, OTTMUSP00000051423, ENSMUST00000022701, OTTMUST00000092874
      Conserved Domains (4) summary
      pfam08934
      Location:761920
      Rb_C; Rb C-terminal domain
      cd00043
      Location:648718
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      pfam01858
      Location:367567
      RB_A; Retinoblastoma-associated protein A domain
      pfam11934
      Location:109222
      DUF3452; Domain of unknown function (DUF3452)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      73194453..73325885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518731.3XP_006518794.1  

      Conserved Domains (2) summary
      pfam01858
      Location:367564
      RB_A; Retinoblastoma-associated protein A domain
      pfam11934
      Location:109222
      DUF3452; Domain of unknown function (DUF3452)

    RNA

    1. XR_383150.3 RNA Sequence