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    OXCT1 3-oxoacid CoA-transferase 1 [ Homo sapiens (human) ]

    Gene ID: 5019, updated on 8-Aug-2016
    Official Symbol
    OXCT1provided by HGNC
    Official Full Name
    3-oxoacid CoA-transferase 1provided by HGNC
    Primary source
    HGNC:HGNC:8527
    See related
    Ensembl:ENSG00000083720 HPRD:02001; MIM:601424; Vega:OTTHUMG00000094783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OXCT; SCOT
    Summary
    This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    5p13.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (41730065..41870689, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (41730167..41870791, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 3 Neighboring gene uncharacterized LOC105374740 Neighboring gene t-complex 1 pseudogene 2 Neighboring gene uncharacterized LOC102723752 Neighboring gene OXCT1 antisense RNA 1 Neighboring gene zinc finger protein 626 pseudogene Neighboring gene ribosomal protein S2 pseudogene 22 Neighboring gene chromosome 5 open reading frame 51

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that OXCT1 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with OXCT1 PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    3-oxoacid CoA-transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    3-oxoacid CoA-transferase activity TAS
    Traceable Author Statement
    more info
     
    protein homodimerization activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    adipose tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    cellular ketone body metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    ketone body catabolic process TAS
    Traceable Author Statement
    more info
     
    ketone catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to hormone IEA
    Inferred from Electronic Annotation
    more info
     
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
    Names
    3-oxoacid CoA transferase 1
    3-oxoacid-CoA transferase 1
    SCOT-s
    somatic-type succinyl CoA:3-oxoacid CoA-transferase
    somatic-type succinyl-CoA:3-oxoacid CoA-transferase
    somatic-type succinyl-CoA:3-oxoacid-CoA-transferase
    succinyl CoA:3-oxoacid CoA transferase
    succinyl-CoA:3-ketoacid-CoA transferase
    succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial
    NP_000427.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011823.1 RefSeqGene

      Range
      5001..145625
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000436.3NP_000427.1  succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_000427.1

      Status: REVIEWED

      Source sequence(s)
      AC034222, BC009001
      Consensus CDS
      CCDS3937.1
      UniProtKB/Swiss-Prot
      P55809
      UniProtKB/TrEMBL
      A0A024R040
      Related
      ENSP00000196371, OTTHUMP00000120012, ENST00000196371, OTTHUMT00000211594
      Conserved Domains (3) summary
      COG1788
      Location:41274
      AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]
      COG4670
      Location:48517
      YdiF; Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid transport and metabolism]
      cl00339
      Location:300508
      SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      41730065..41870689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009494.1XP_016864983.1  

    RNA

    1. XR_427658.3 RNA Sequence

    2. XR_001742081.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      41732020..41872646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)