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    IL4 interleukin 4 [ Homo sapiens (human) ]

    Gene ID: 3565, updated on 24-Apr-2016
    Official Symbol
    IL4provided by HGNC
    Official Full Name
    interleukin 4provided by HGNC
    Primary source
    HGNC:HGNC:6014
    See related
    Ensembl:ENSG00000113520 HPRD:00989; MIM:147780; Vega:OTTHUMG00000059724
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BSF1; IL-4; BCGF1; BSF-1; BCGF-1
    Summary
    The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    5q31.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (132673986..132682678)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132009678..132018370)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RAD50 double strand break repair protein Neighboring gene T helper type 2 locus control region associated RNA Neighboring gene uncharacterized LOC105379176 Neighboring gene interleukin 13 Neighboring gene kinesin family member 3A Neighboring gene cyclin I family member 2 Neighboring gene septin 8

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 induces release of IL-4 in CD4+ T cells PubMed
    env HIV-1 gp120 cooperates with BAFF and cytokines IL-4 and IL-10 to activate mannose C-type lectin receptors-expressing B cells PubMed
    env HIV-1 gp120 upregulates IL-4-induced IgE production through the regulation of the nitric oxide pathway PubMed
    env Molecular interactions of CD2 with LFA-3 and CD28 with B7-1 in conjunction with TCR occupancy prevent T cells from programmed apoptosis mediated by binding of CD4 to HIV-1 gp120, resulting in increased levels of IL-2 and IL-4 secretion from the T cells PubMed
    env Antigen-induced interleukin 4 secretion is markedly reduced in HIV-1 gp120-treated T cells PubMed
    Envelope surface glycoprotein gp160, precursor env Pretreatment of CD4+ cells with HIV-1 gp160 significantly reduces PHA-induced secretion of IFN-gamma and IL-2 but augments IL-4 production PubMed
    Nef nef HIV-1 Nef suppresses immunoglobulin class-switch DNA recombination by inducing IkappaBalpha and SOCS proteins, which block CD154, IL-4 and IL-10 cytokine signaling via NF-kappaB and STAT transcription factors PubMed
    Tat tat HIV-1 Tat significantly decreases TNF-alpha and IL-6 secretion but increases IL-4 levels in human hepatocellular carcinoma cells PubMed
    tat Monocytes treated with HIV-1 clade C Tat show significant upregulation of anti-inflammatory cytokines, IL-4 and IL-10, as compared to clade B Tat-treated cultures PubMed
    tat Activation of IL-4/STAT6 signaling partially contributes to HIV-1 Tat-induced Kaposi's sarcoma-associated herpes virus (KSHV) replication PubMed
    tat HIV-1 Tat upregulates IL-4 expression in Jurkat T-cells PubMed
    tat HIV-1 Tat induces IL-4 and IL-13 release from basophils, leading to dysregulation of the IgE/Fc epsilon RI network PubMed
    Vif vif HIV-1 Vif upregulates the expression of interleukin 4 (IL4) in Vif-expression T cells PubMed
    Vpr vpr HIV-1 Vpr suppresses expression of IL-4 through suppression of NF-kappa B activity via the induction of I kappa B alpha PubMed
    integrase gag-pol Treatment of resting CD4+ T cells with cytokines IL-2, IL-4, IL-7, or IL15 enhances HIV-1 IN mutant D116N to generate de novo virus production PubMed
    matrix gag HIV-1 Matrix slightly enhances TNF-alpha and IFN-gamma secretion induced by IL-15 monocyte stimulation and counteracts IL-4 mediated inhibition of the production of these cytokines PubMed
    gag HIV-1 Matrix blocks IL-4 downregulation of interferon gamma and TNF-alpha PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC79402

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    growth factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    interleukin-4 receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell costimulation IEA
    Inferred from Electronic Annotation
    more info
     
    B cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    T-helper 1 cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
     
    T-helper 2 cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    T-helper 2 cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to mercury ion IEA
    Inferred from Electronic Annotation
    more info
     
    chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    cholesterol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    connective tissue growth factor biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    defense response to protozoan IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response in mucosa IEA
    Inferred from Electronic Annotation
    more info
     
    microglial cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    myeloid dendritic cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of T-helper 17 cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of acute inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of chronic inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of complement-dependent cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endothelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of macrophage activation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of osteoclast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of white fat cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of MHC class II biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of activated T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of defense response to virus by host IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of eosinophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-13 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of isotype switching to IgE isotypes ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of isotype switching to IgG isotypes ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mononuclear cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of myoblast fusion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of Stat5 protein IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of isotype switching TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of proton transport IEA
    Inferred from Electronic Annotation
    more info
     
    response to cytokine IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    retina development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    type 2 immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    interleukin-4
    Names
    B cell growth factor 1
    B_cell stimulatory factor 1
    binetrakin
    interleukin 4 variant 2
    lymphocyte stimulatory factor 1
    pitrakinra

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023252.1 RefSeqGene

      Range
      5306..13998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000589.3NP_000580.1  interleukin-4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_000580.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes a longer isoform (1).
      Source sequence(s)
      BC067514, CD640452, M13982
      Consensus CDS
      CCDS4158.1
      UniProtKB/Swiss-Prot
      P05112
      UniProtKB/TrEMBL
      D4HNR6
      Related
      ENSP00000231449, OTTHUMP00000066049, ENST00000231449, OTTHUMT00000132786
      Conserved Domains (1) summary
      pfam00727
      Location:25149
      IL4; Interleukin 4
    2. NM_172348.2NP_758858.1  interleukin-4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_758858.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' region, compared to variant 1, resulting an isoform (2) that lacks an internal region, as compared to isoform 1.
      Source sequence(s)
      AB102862, BC067514, CD640452, M13982
      Consensus CDS
      CCDS4159.1
      UniProtKB/Swiss-Prot
      P05112
      UniProtKB/TrEMBL
      Q5FC01
      Related
      ENSP00000325190, OTTHUMP00000066050, ENST00000350025, OTTHUMT00000132787
      Conserved Domains (1) summary
      pfam00727
      Location:25133
      IL4; Interleukin 4

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

      Range
      132673986..132682678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      131442973..131451670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)