Display Settings:

Format

Send to:

Choose Destination

BTG1 B-cell translocation gene 1, anti-proliferative [ Homo sapiens (human) ]

Gene ID: 694, updated on 13-Sep-2014
Official Symbol
BTG1provided by HGNC
Official Full Name
B-cell translocation gene 1, anti-proliferativeprovided by HGNC
Primary source
HGNC:HGNC:1130
See related
Ensembl:ENSG00000133639; HPRD:15912; MIM:109580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]
See BTG1 in Epigenomics, MapViewer
Location:
12q22
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (92140278..92145897, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (92534054..92539673, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928584 Neighboring gene lumican Neighboring gene decorin Neighboring gene chromosome 12 open reading frame 79 Neighboring gene uncharacterized LOC101928617 Neighboring gene ribosomal protein L21 pseudogene 106 Neighboring gene chronic lymphocytic leukemia up-regulated 1 opposite strand Neighboring gene chronic lymphocytic leukemia up-regulated 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.
NHGRI GWA Catalog
  • Diurnally regulated genes with circadian orthologs, organism-specific biosystem (from WikiPathways)
    Diurnally regulated genes with circadian orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription cofactor activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Preferred Names
protein BTG1
Names
protein BTG1
B-cell translocation gene 1 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001731.2NP_001722.1  protein BTG1

    See proteins identical to NP_001722.1

    Status: REVIEWED

    Source sequence(s)
    AC025164, AK313309, BC009050, BC064953, DB042281, X61123
    Consensus CDS
    CCDS9043.1
    UniProtKB/Swiss-Prot
    P62324
    UniProtKB/TrEMBL
    Q6IBC8
    Related
    ENSP00000256015, OTTHUMP00000242800, ENST00000256015, OTTHUMT00000407227
    Conserved Domains (1) summary
    smart00099
    Location:11118
    Blast Score: 524
    btg1; tob/btg1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    92140278..92145897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    89601434..89607055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    92499080..92504699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)