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    Creb1 cAMP responsive element binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81646, updated on 19-Jul-2016
    Official Symbol
    Creb1provided by RGD
    Official Full Name
    cAMP responsive element binding protein 1provided by RGD
    Primary source
    RGD:620218
    See related
    Ensembl:ENSRNOG00000013412
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Creb
    Summary
    binds the cAMP response element in many gene promoters and regulates transcription [RGD, Feb 2006]
    Orthologs
    Location:
    9q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (71229799..71298994)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (71277171..71346198, complement)

    Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene high mobility group protein HMG-I/HMG-Y-like Neighboring gene small integral membrane protein 7-like Neighboring gene methyltransferase like 21A Neighboring gene uncharacterized LOC102556685

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp70 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase II activating transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II distal enhancer sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II distal enhancer sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    arrestin family protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cAMP response element binding IEA
    Inferred from Electronic Annotation
    more info
     
    cAMP response element binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    regulatory region DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional activator activity, RNA polymerase II transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Type I pneumocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Type I pneumocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hepatocyte growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hepatocyte growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin-like growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to nerve growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to platelet-derived growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to zinc ion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to zinc ion ISO
    Inferred from Sequence Orthology
    more info
     
    chemotaxis to arachidonic acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    lactation IEA
    Inferred from Electronic Annotation
    more info
     
    lactation ISO
    Inferred from Sequence Orthology
    more info
     
    lung epithelium development ISO
    Inferred from Sequence Orthology
    more info
     
    lung saccule development IEA
    Inferred from Electronic Annotation
    more info
     
    lung saccule development ISO
    Inferred from Sequence Orthology
    more info
     
    mammary gland development ISO
    Inferred from Sequence Orthology
    more info
     
    memory IEA
    Inferred from Electronic Annotation
    more info
     
    memory ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by competitive promoter binding IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by competitive promoter binding ISO
    Inferred from Sequence Orthology
    more info
     
    pituitary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    pituitary gland development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cardiac muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transforming growth factor beta3 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    response to L-glutamate IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to glucagon ISO
    Inferred from Sequence Orthology
    more info
     
    response to glucagon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nicotine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule organization IEA
    Inferred from Electronic Annotation
    more info
     
    secretory granule organization ISO
    Inferred from Sequence Orthology
    more info
     
    transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    ATF4-CREB1 transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    ATF4-CREB1 transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear euchromatin IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    cyclic AMP-responsive element-binding protein 1
    Names
    CREB-1
    Y protein
    cAMP response element binding protein 1
    cAMP-responsive element-binding protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031017.1NP_112279.1  cyclic AMP-responsive element-binding protein 1 isoform B

      See identical proteins and their annotated locations for NP_112279.1

      Status: PROVISIONAL

      Source sequence(s)
      X14788
      UniProtKB/Swiss-Prot
      P15337
      Related
      ENSRNOP00000018326, ENSRNOT00000018326
      Conserved Domains (2) summary
      pfam02173
      Location:113151
      pKID; pKID domain
      cd14690
      Location:285339
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    2. NM_134443.1NP_604392.1  cyclic AMP-responsive element-binding protein 1 isoform A

      See identical proteins and their annotated locations for NP_604392.1

      Status: PROVISIONAL

      Source sequence(s)
      X60002
      UniProtKB/Swiss-Prot
      P15337
      Related
      ENSRNOP00000049369, ENSRNOT00000049654
      Conserved Domains (2) summary
      cd14690
      Location:271325
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:99137
      pKID; pKID domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

      Range
      71229799..71298994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245065.2XP_006245127.1  

      See identical proteins and their annotated locations for XP_006245127.1

      UniProtKB/Swiss-Prot
      P15337
      Conserved Domains (2) summary
      pfam02173
      Location:113151
      pKID; pKID domain
      cd14690
      Location:285339
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    2. XM_006245066.2XP_006245128.1  

      See identical proteins and their annotated locations for XP_006245128.1

      UniProtKB/Swiss-Prot
      P15337
      Conserved Domains (2) summary
      pfam02173
      Location:99137
      pKID; pKID domain
      cd14690
      Location:271325
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    3. XM_006245067.2XP_006245129.1  

      See identical proteins and their annotated locations for XP_006245129.1

      Conserved Domains (2) summary
      pfam02173
      Location:73111
      pKID; pKID domain
      cd14690
      Location:245299
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    4. XM_006245068.2XP_006245130.1  

      See identical proteins and their annotated locations for XP_006245130.1

      Conserved Domains (2) summary
      pfam02173
      Location:1553
      pKID; pKID domain
      cd14690
      Location:187241
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    5. XM_008767138.1XP_008765360.1  

      See identical proteins and their annotated locations for XP_008765360.1

      Conserved Domains (2) summary
      pfam02173
      Location:1553
      pKID; pKID domain
      cd14690
      Location:187241
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    6. XM_006245069.2XP_006245131.1  

      See identical proteins and their annotated locations for XP_006245131.1

      Conserved Domains (2) summary
      pfam02173
      Location:1553
      pKID; pKID domain
      cd14690
      Location:187241
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    7. XM_006245070.2XP_006245132.1  

      See identical proteins and their annotated locations for XP_006245132.1

      Conserved Domains (1) summary
      cd14690
      Location:55109
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    8. XM_008767139.1XP_008765361.1  

      See identical proteins and their annotated locations for XP_008765361.1

      Conserved Domains (1) summary
      cd14690
      Location:55109
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    Alternate Rn_Celera

    Genomic

    1. AC_000077.1 Alternate Rn_Celera

      Range
      63310784..63374139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)