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IGFBP2 insulin-like growth factor binding protein 2, 36kDa [ Homo sapiens (human) ]

Gene ID: 3485, updated on 6-Jul-2014
Official Symbol
IGFBP2provided by HGNC
Official Full Name
insulin-like growth factor binding protein 2, 36kDaprovided by HGNC
Primary source
HGNC:5471
See related
Ensembl:ENSG00000115457; HPRD:00898; MIM:146731; Vega:OTTHUMG00000155341
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IBP2; IGF-BP53
See IGFBP2 in Epigenomics, MapViewer
Location:
2q33-q34
Exon count :
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (216633404..216664436)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217498127..217529159)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1280 Neighboring gene proteasome (prosome, macropain) subunit, beta type, 3 pseudogene 2 Neighboring gene insulin-like growth factor binding protein 5 Neighboring gene ribosomal protein L31 pseudogene 14

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
insulin-like growth factor I binding IDA
Inferred from Direct Assay
more info
PubMed 
insulin-like growth factor II binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
positive regulation of activated T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin-like growth factor receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
regulation of insulin-like growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to lithium ion IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
Preferred Names
insulin-like growth factor-binding protein 2
Names
insulin-like growth factor-binding protein 2
IBP-2
IGFBP-2
IGF-binding protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000597.2NP_000588.2  insulin-like growth factor-binding protein 2 precursor

    See proteins identical to NP_000588.2

    Status: VALIDATED

    Source sequence(s)
    AL559513, BC071967, M35410
    Consensus CDS
    CCDS42815.1
    UniProtKB/Swiss-Prot
    P18065
    Related
    ENSP00000233809, OTTHUMP00000207751, ENST00000233809, OTTHUMT00000339540
    Conserved Domains (2) summary
    smart00121
    Location:43135
    Blast Score: 236
    IB; Insulin growth factor-binding protein homologues
    cd00191
    Location:229309
    Blast Score: 161
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    216633404..216664436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    209352529..209383563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    217504294..217535337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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