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TREM1 triggering receptor expressed on myeloid cells 1 [ Homo sapiens (human) ]

Gene ID: 54210, updated on 21-Jul-2014
Official Symbol
TREM1provided by HGNC
Official Full Name
triggering receptor expressed on myeloid cells 1provided by HGNC
Primary source
HGNC:17760
See related
Ensembl:ENSG00000124731; HPRD:05472; MIM:605085; Vega:OTTHUMG00000014674
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD354; TREM-1
Summary
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
See TREM1 in Epigenomics, MapViewer
Location:
6p21.1
Exon count :
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (41267386..41286719, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41242999..41254457, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 207 Neighboring gene triggering receptor expressed on myeloid cells-like 5, pseudogene Neighboring gene ribosomal protein L32 pseudogene 15 Neighboring gene natural cytotoxicity triggering receptor 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of triggering receptor expressed on myeloid cells 1 (TREM1) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • DAP12 interactions, organism-specific biosystem (from REACTOME)
    DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
receptor activity TAS
Traceable Author Statement
more info
PubMed 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
blood coagulation TAS
Traceable Author Statement
more info
 
humoral immune response TAS
Traceable Author Statement
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
triggering receptor expressed on myeloid cells 1
Names
triggering receptor expressed on myeloid cells 1
triggering-receptor TREM1
triggering receptor expressed on monocytes 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029525.1 

    Range
    5001..16459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242589.1NP_001229518.1  triggering receptor expressed on myeloid cells 1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a shorter isoform (2) with a distinct C-terminus, lacking the transmembrane domain, compared to isoform 1.
    Source sequence(s)
    AF287008, AK223264
    Consensus CDS
    CCDS59499.1
    UniProtKB/Swiss-Prot
    Q9NP99
    Related
    ENSP00000465345, OTTHUMP00000267883, ENST00000591620, OTTHUMT00000458284
    Conserved Domains (1) summary
    cl11960
    Location:33118
    Blast Score: 120
    Ig; Immunoglobulin domain
  2. NM_001242590.1NP_001229519.1  triggering receptor expressed on myeloid cells 1 isoform 3 precursor

    See proteins identical to NP_001229519.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is missing an internal coding exon compared to variant 1. This results in a frame-shift, and a shorter isoform (3) with a distinct C-terminus compared to isoform 1. This isoform, lacking the transmembrane domain, is likely secreted, and may function as a regulator of myeloid activation (PMID:11922939).
    Source sequence(s)
    AF287008, AK301519, DA362458, DA938757
    Consensus CDS
    CCDS56427.1
    UniProtKB/Swiss-Prot
    Q9NP99
    Conserved Domains (2) summary
    smart00410
    Location:27133
    Blast Score: 73
    IG_like; Immunoglobulin like
    cl11960
    Location:33118
    Blast Score: 118
    Ig; Immunoglobulin domain
  3. NM_018643.3NP_061113.1  triggering receptor expressed on myeloid cells 1 isoform 1 precursor

    See proteins identical to NP_061113.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF287008, DA362458, DA938757
    Consensus CDS
    CCDS4854.1
    UniProtKB/TrEMBL
    Q38L15
    UniProtKB/Swiss-Prot
    Q9NP99
    Related
    ENSP00000244709, OTTHUMP00000016370, ENST00000244709, OTTHUMT00000040505
    Conserved Domains (1) summary
    cl11960
    Location:33118
    Blast Score: 122
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    41267386..41286719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715117.1XP_006715180.1  

    Conserved Domains (2) summary
    smart00410
    Location:27133
    Blast Score: 75
    IG_like; Immunoglobulin like
    cl11960
    Location:33118
    Blast Score: 120
    Ig; Immunoglobulin domain

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    40961518..40972978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    41246251..41257709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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