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    Bcl11a B cell CLL/lymphoma 11A (zinc finger protein) [ Mus musculus (house mouse) ]

    Gene ID: 14025, updated on 7-Feb-2016
    Official Symbol
    Bcl11aprovided by MGI
    Official Full Name
    B cell CLL/lymphoma 11A (zinc finger protein)provided by MGI
    Primary source
    MGI:MGI:106190
    See related
    Ensembl:ENSMUSG00000000861; Vega:OTTMUSG00000005291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Evi9; Ctip1; Evi9a; Evi9b; Evi9c; BCL-11A; mKIAA1809; 2810047E18Rik; D930021L15Rik
    Orthologs
    See Bcl11a in Epigenomics, MapViewer
    Location:
    11; 11 A3.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (24076564..24173558)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (23978056..24073558)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene poly(A) polymerase gamma Neighboring gene predicted gene 12061 Neighboring gene predicted gene, 33232 Neighboring gene RIKEN cDNA 4930538E20 gene Neighboring gene predicted gene 12066 Neighboring gene predicted gene, 33440 Neighboring gene predicted gene, 33379

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription regulatory region DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of collateral sprouting ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of collateral sprouting ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    B-cell lymphoma/leukemia 11A
    Names
    B-cell CLL/lymphoma 11A (zinc finger protein)
    COUP-TF interacting protein 1
    COUP-TF-interacting protein 1
    EVI-9
    ecotropic viral integration site 9 protein
    myeloid leukemia

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159289.1NP_001152761.1  B-cell lymphoma/leukemia 11A isoform 2

      See identical proteins and their annotated locations for NP_001152761.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 3' coding region, compared to variant 4. The resulting protein (isoform 2) has a shorter C-terminus when it is compared to isoform 4.
      Source sequence(s)
      AA008362, AK004395, AK045556, BB853515, BY735002
      Consensus CDS
      CCDS48758.1
      UniProtKB/Swiss-Prot
      Q9QYE3
    2. NM_001159290.1NP_001152762.1  B-cell lymphoma/leukemia 11A isoform 3

      See identical proteins and their annotated locations for NP_001152762.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences, one of which results in the use of a downstream start codon, compared to variant 4. The resulting protein (isoform 3) is shorter when it is compared to isoform 4.
      Source sequence(s)
      AK045556
      Consensus CDS
      CCDS48759.1
      UniProtKB/Swiss-Prot
      Q9QYE3
      Related
      ENSMUSP00000112948, OTTMUSP00000005475, ENSMUST00000118955, OTTMUST00000011801
    3. NM_001242934.1NP_001229863.1  B-cell lymphoma/leukemia 11A isoform 4

      See identical proteins and their annotated locations for NP_001229863.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest protein (isoform 4).
      Source sequence(s)
      AK045556, AK140949, AK164574, BB649527, BB662872, BF731393, BY735002, CB524780, CD355476
      Consensus CDS
      CCDS56764.1
      UniProtKB/TrEMBL
      Q3TP99
      UniProtKB/TrEMBL
      Q3US10
      UniProtKB/TrEMBL
      Q5STS9
      UniProtKB/Swiss-Prot
      Q9QYE3
      Related
      ENSMUSP00000105140, OTTMUSP00000005479, ENSMUST00000109514, OTTMUST00000011806
      Conserved Domains (3) summary
      pfam00096
      Location:743764
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:756781
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:744764
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. NM_016707.3NP_057916.1  B-cell lymphoma/leukemia 11A isoform 1

      See identical proteins and their annotated locations for NP_057916.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses a different splice site in the 3' coding region, compared to variant 4. The resulting protein (isoform 1) has a shorter C-terminus when it is compared to isoform 4.
      Source sequence(s)
      AF169037, AL672018, BB649527, BY735002
      Consensus CDS
      CCDS24483.1
      UniProtKB/Swiss-Prot
      Q9QYE3
      Related
      ENSMUSP00000000881, OTTMUSP00000005476, ENSMUST00000000881, OTTMUST00000011803
      Conserved Domains (3) summary
      pfam00096
      Location:378399
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:391416
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:379399
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

      Range
      24076564..24173558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514504.2XP_006514567.1  

      See identical proteins and their annotated locations for XP_006514567.1

      UniProtKB/TrEMBL
      Q5STS9
      Conserved Domains (3) summary
      pfam00096
      Location:743764
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:756781
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:744764
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_011243661.1XP_011241963.1  

      See identical proteins and their annotated locations for XP_011241963.1

      UniProtKB/TrEMBL
      Q5STS9
      Conserved Domains (3) summary
      pfam00096
      Location:743764
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:756781
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:744764
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. XM_006514506.2XP_006514569.1  

      See identical proteins and their annotated locations for XP_006514569.1

      UniProtKB/TrEMBL
      Q5STS9
      Conserved Domains (3) summary
      pfam00096
      Location:743764
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:756781
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:744764
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. XM_006514505.2XP_006514568.1  

      See identical proteins and their annotated locations for XP_006514568.1

      UniProtKB/TrEMBL
      Q5STS9
      Conserved Domains (3) summary
      pfam00096
      Location:743764
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:756781
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:744764
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. XM_011243660.1XP_011241962.1  

      Conserved Domains (3) summary
      pfam00096
      Location:709730
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:722747
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:710730
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. XM_011243659.1XP_011241961.1  

      Conserved Domains (4) summary
      pfam00096
      Location:743764
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:756781
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:379399
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:744764
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. XM_006514507.2XP_006514570.1  

      Conserved Domains (3) summary
      pfam00096
      Location:691712
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:704729
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:692712
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate Mm_Celera

    Genomic

    1. AC_000033.1 Alternate Mm_Celera

      Range
      26200322..26297352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)