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TAS2R38 taste receptor, type 2, member 38 [ Homo sapiens (human) ]

Gene ID: 5726, updated on 7-Dec-2014
Official Symbol
TAS2R38provided by HGNC
Official Full Name
taste receptor, type 2, member 38provided by HGNC
Primary source
HGNC:HGNC:9584
Locus tag
tcag7.360
See related
Ensembl:ENSG00000257138; HPRD:09672; MIM:607751; Vega:OTTHUMG00000158374
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTC; T2R38; T2R61
Summary
This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]
See TAS2R38 in Epigenomics, MapViewer
Location:
7q34
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (141972631..141973773, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141672431..141673573, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene maltase-glucoamylase (alpha-glucosidase) Neighboring gene olfactory receptor, family 9, subfamily A, member 4 Neighboring gene C-type lectin domain family 5, member A Neighboring gene maltase-glucoamylase (alpha-glucosidase) Neighboring gene monooxygenase, DBH-like 2, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Thiourea tasting
MedGen: C1868397 OMIM: 171200 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genetic variants associated with disordered eating.
NHGRI GWA Catalog
GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics.
NHGRI GWA Catalog
The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12.
NHGRI GWA Catalog
  • Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystem (from REACTOME)
    Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystemThe class C G-protein-coupled receptors are a class of G-protein coupled receptors that include the metabotropic glutamate receptors and several additional receptors (Brauner-Osborne H et al, 2007). ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Taste transduction, organism-specific biosystem (from KEGG)
    Taste transduction, organism-specific biosystemAll taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na...
  • Taste transduction, conserved biosystem (from KEGG)
    Taste transduction, conserved biosystemAll taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na...

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
bitter taste receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IC
Inferred by Curator
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
taste receptor type 2 member 38
Names
taste receptor type 2 member 38
PTC bitter taste receptor
taste receptor type 2 member 61

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016141.1 

    Range
    5001..6143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176817.4NP_789787.4  taste receptor type 2 member 38

    See proteins identical to NP_789787.4

    Status: REVIEWED

    Source sequence(s)
    BC104933
    Consensus CDS
    CCDS34765.1
    UniProtKB/Swiss-Prot
    P59533
    Related
    ENSP00000448219, OTTHUMP00000212847, ENST00000547270, OTTHUMT00000350810
    Conserved Domains (1) summary
    pfam05296
    Location:16314
    TAS2R; Mammalian taste receptor protein (TAS2R)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    141972631..141973773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    141606660..141607802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    135968803..135969945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)