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Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) [ Mus musculus (house mouse) ]

Gene ID: 12575, updated on 26-Aug-2014
Official Symbol
Cdkn1aprovided by MGI
Official Full Name
cyclin-dependent kinase inhibitor 1A (P21)provided by MGI
Primary source
MGI:104556
See related
Ensembl:ENSMUSG00000023067; Vega:OTTMUSG00000031654
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P21; CDKI; CIP1; SDI1; Waf1; mda6; CAP20; Cdkn1; p21WAF; p21Cip1
See Cdkn1a in Epigenomics, MapViewer
Location:
17 A3.3; 17 15.12 cM
Exon count:
4
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 17 NC_000083.6 (29090986..29100722)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene serine/arginine-rich splicing factor 3 Neighboring gene tumor protein p53 pathway corepressor 1 Neighboring gene RAB44, member RAS oncogene family Neighboring gene ribosomal protein L35A, pseudogene 3 Neighboring gene somatostatin receptor 4 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cyclin binding IDA
Inferred from Direct Assay
more info
PubMed 
cyclin-dependent protein kinase activating kinase activity ISO
Inferred from Sequence Orthology
more info
 
cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to extracellular stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
cellular senescence ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of DNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein import into nucleus, translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
PCNA-p21 complex ISO
Inferred from Sequence Orthology
more info
 
cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cyclin-dependent kinase inhibitor 1
Names
cyclin-dependent kinase inhibitor 1
p21<WAF1/CIP1>
CDK-interacting protein 1
melanoma differentiation-associated protein
cyclin-dependent kinase inhibitor 1A variant 1
cyclin-dependent kinase inhibitor 1A variant 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111099.1NP_001104569.1  cyclin-dependent kinase inhibitor 1

    See proteins identical to NP_001104569.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK007630, AK149910, BY206886
    Consensus CDS
    CCDS28591.1
    UniProtKB/Swiss-Prot
    P39689
    UniProtKB/TrEMBL
    Q564P6
    Conserved Domains (1) summary
    pfam02234
    Location:1868
    Blast Score: 209
    CDI; Cyclin-dependent kinase inhibitor
  2. NM_007669.4NP_031695.1  cyclin-dependent kinase inhibitor 1

    See proteins identical to NP_031695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK007630, AK149910
    Consensus CDS
    CCDS28591.1
    UniProtKB/Swiss-Prot
    P39689
    UniProtKB/TrEMBL
    Q564P6
    Related
    ENSMUSP00000023829, OTTMUSP00000041697, ENSMUST00000023829, OTTMUST00000078425
    Conserved Domains (1) summary
    pfam02234
    Location:1868
    Blast Score: 209
    CDI; Cyclin-dependent kinase inhibitor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000083.6 

    Range
    29090986..29100722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p2 NOD/ShiLtJ

Genomic

  1. NT_187005.1 

    Range
    1789868..1799619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000039.1 

    Range
    29647617..29657304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)