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G6pc glucose-6-phosphatase, catalytic subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 25634, updated on 26-Aug-2014
Official Symbol
G6pcprovided by RGD
Official Full Name
glucose-6-phosphatase, catalytic subunitprovided by RGD
Primary source
RGD:2644
See related
Ensembl:ENSRNOG00000036806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
G6Pase
Summary
catalyzes the conversion of D-glucose 6-phosphate and H2O to D-glucose and phosphate in gluconeogenesis [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
See G6pc in MapViewer
Location:
10q32.1
Exon count:
5
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89286009..89296213)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (89084064..89094265)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene amine oxidase, copper containing 2 (retina-specific), pseudogene 1 Neighboring gene amine oxidase, copper containing 3 Neighboring gene uncharacterized LOC103693431 Neighboring gene alanyl-tRNA synthetase domain containing 1 Neighboring gene prostaglandin E synthase 3 (cytosolic)-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
    Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
    Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Carbohydrate digestion and absorption, organism-specific biosystem (from KEGG)
    Carbohydrate digestion and absorption, organism-specific biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
  • Carbohydrate digestion and absorption, conserved biosystem (from KEGG)
    Carbohydrate digestion and absorption, conserved biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Galactose metabolism, organism-specific biosystem (from KEGG)
    Galactose metabolism, organism-specific biosystem
    Galactose metabolism
  • Galactose metabolism, conserved biosystem (from KEGG)
    Galactose metabolism, conserved biosystem
    Galactose metabolism
  • Glycolysis / Gluconeogenesis, organism-specific biosystem (from KEGG)
    Glycolysis / Gluconeogenesis, organism-specific biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
  • Glycolysis / Gluconeogenesis, conserved biosystem (from KEGG)
    Glycolysis / Gluconeogenesis, conserved biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
  • Glycolysis and Gluconeogenesis, organism-specific biosystem (from WikiPathways)
    Glycolysis and Gluconeogenesis, organism-specific biosystem
    Glycolysis and Gluconeogenesis
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Proteasome Degradation, organism-specific biosystem (from WikiPathways)
    Proteasome Degradation, organism-specific biosystem
    Proteasome Degradation
  • Starch and sucrose metabolism, organism-specific biosystem (from KEGG)
    Starch and sucrose metabolism, organism-specific biosystem
    Starch and sucrose metabolism
  • Starch and sucrose metabolism, conserved biosystem (from KEGG)
    Starch and sucrose metabolism, conserved biosystem
    Starch and sucrose metabolism
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC93613

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
cation channel activity IEA
Inferred from Electronic Annotation
more info
 
copper ion binding IEA
Inferred from Electronic Annotation
more info
 
glucose-6-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
glucose-6-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
glucose-6-phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
phosphate ion binding ISO
Inferred from Sequence Orthology
more info
 
phosphotransferase activity, alcohol group as acceptor ISO
Inferred from Sequence Orthology
more info
 
primary amine oxidase activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
quinone binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
amine metabolic process IEA
Inferred from Electronic Annotation
more info
 
cation transport IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
gluconeogenesis TAS
Traceable Author Statement
more info
PubMed 
glucose 6-phosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glucose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
glucose-6-phosphate transport ISO
Inferred from Sequence Orthology
more info
 
glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
 
glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
 
lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
phosphate-containing compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylated carbohydrate dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
response to antibiotic IEA
Inferred from Electronic Annotation
more info
 
response to food IEP
Inferred from Expression Pattern
more info
PubMed 
steroid metabolic process ISO
Inferred from Sequence Orthology
more info
 
triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
urate metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
microvillus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
proteasome activator complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
glucose-6-phosphatase
Names
glucose-6-phosphatase
G-6-Pase
NP_037230.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013098.2NP_037230.2  glucose-6-phosphatase

    See proteins identical to NP_037230.2

    Status: VALIDATED

    Source sequence(s)
    BC090067
    UniProtKB/Swiss-Prot
    P43428
    Related
    ENSRNOP00000028033, ENSRNOT00000028033
    Conserved Domains (2) summary
    COG0671
    Location:39192
    Blast Score: 118
    PgpB; Membrane-associated phospholipid phosphatase [Lipid metabolism]
    cd03381
    Location:42280
    Blast Score: 904
    PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 

    Range
    89286009..89296213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 

    Range
    85025492..85036580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)