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    PRPF31 pre-mRNA processing factor 31 [ Homo sapiens (human) ]

    Gene ID: 26121, updated on 24-Aug-2015
    Official Symbol
    PRPF31provided by HGNC
    Official Full Name
    pre-mRNA processing factor 31provided by HGNC
    Primary source
    HGNC:HGNC:15446
    See related
    Ensembl:ENSG00000105618; HPRD:05917; MIM:606419; Vega:OTTHUMG00000066040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RP11; PRP31; SNRNP61; NY-BR-99
    Summary
    This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009]
    Orthologs
    See PRPF31 in Epigenomics, MapViewer
    Location:
    19q13.42
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (54115376..54131719)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54618790..54635150)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa Neighboring gene uncharacterized LOC105372458 Neighboring gene TCF3 (E2A) fusion partner (in childhood Leukemia) Neighboring gene CCR4-NOT transcription complex, subunit 3 Neighboring gene uncharacterized LOC102724273 Neighboring gene leukocyte receptor cluster (LRC) member 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, pre-mRNA processing factor 31 homolog (PRPF31), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, U4/U6.U5 tri-snRNP, organism-specific biosystem (from KEGG)
      Spliceosome, U4/U6.U5 tri-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • Spliceosome, U4/U6.U5 tri-snRNP, conserved biosystem (from KEGG)
      Spliceosome, U4/U6.U5 tri-snRNP, conserved biosystemStructural complex; Genetic information processing; Spliceosome
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp566J153

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    snRNP binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spliceosomal tri-snRNP complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spliceosomal tri-snRNP complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MLL1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    U2-type spliceosomal complex IC
    Inferred by Curator
    more info
    PubMed 
    U4 snRNP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    U4atac snRNP TAS
    Traceable Author Statement
    more info
    PubMed 
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    U4/U6 small nuclear ribonucleoprotein Prp31
    Names
    PRP31 pre-mRNA processing factor 31 homolog
    U4/U6 snRNP 61 kDa protein
    hPrp31
    pre-mRNA-processing factor 31
    protein 61K
    serologically defined breast cancer antigen NY-BR-99

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009759.1 RefSeqGene

      Range
      5001..21361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015629.3NP_056444.3  U4/U6 small nuclear ribonucleoprotein Prp31

      See identical proteins and their annotated locations for NP_056444.3

      Status: REVIEWED

      Source sequence(s)
      BC117389, CB854773, CN306666
      Consensus CDS
      CCDS12879.1
      UniProtKB/TrEMBL
      F1T0A5
      UniProtKB/Swiss-Prot
      Q8WWY3
      Related
      ENSP00000324122, OTTHUMP00000068806, ENST00000321030, OTTHUMT00000141417
      Conserved Domains (4) summary
      COG1498
      Location:76346
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam01798
      Location:190334
      Nop; Putative snoRNA binding domain
      pfam08060
      Location:93144
      NOSIC; NOSIC (NUC001) domain
      pfam09785
      Location:336465
      Prp31_C; Prp31 C terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

      Range
      54115376..54131719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006723137.2XP_006723200.1  

      See identical proteins and their annotated locations for XP_006723200.1

      UniProtKB/TrEMBL
      F1T0A5
      UniProtKB/Swiss-Prot
      Q8WWY3
      Conserved Domains (4) summary
      COG1498
      Location:76346
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam01798
      Location:190334
      Nop; Putative snoRNA binding domain
      pfam08060
      Location:93144
      NOSIC; NOSIC (NUC001) domain
      pfam09785
      Location:336465
      Prp31_C; Prp31 C terminal domain

    RNA

    1. XR_935789.1 RNA Sequence

    Reference GRCh38.p2 ALT_REF_LOCI_1

    Genomic

    1. NW_003571054.1 Reference GRCh38.p2 ALT_REF_LOCI_1

      Range
      89869..106263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006726273.2XP_006726336.1  

      See identical proteins and their annotated locations for XP_006726336.1

      UniProtKB/TrEMBL
      F1T0A5
      UniProtKB/Swiss-Prot
      Q8WWY3
      Conserved Domains (4) summary
      COG1498
      Location:76346
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam01798
      Location:190334
      Nop; Putative snoRNA binding domain
      pfam08060
      Location:93144
      NOSIC; NOSIC (NUC001) domain
      pfam09785
      Location:336465
      Prp31_C; Prp31 C terminal domain

    RNA

    1. XR_952190.1 RNA Sequence

    Reference GRCh38.p2 ALT_REF_LOCI_2

    Genomic

    1. NW_003571055.2 Reference GRCh38.p2 ALT_REF_LOCI_2

      Range
      89869..106263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006726055.2XP_006726118.1  

      See identical proteins and their annotated locations for XP_006726118.1

      UniProtKB/TrEMBL
      F1T0A5
      UniProtKB/Swiss-Prot
      Q8WWY3
      Conserved Domains (4) summary
      COG1498
      Location:76346
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam01798
      Location:190334
      Nop; Putative snoRNA binding domain
      pfam08060
      Location:93144
      NOSIC; NOSIC (NUC001) domain
      pfam09785
      Location:336465
      Prp31_C; Prp31 C terminal domain

    RNA

    1. XR_952525.1 RNA Sequence

    Reference GRCh38.p2 ALT_REF_LOCI_3

    Genomic

    1. NW_003571056.2 Reference GRCh38.p2 ALT_REF_LOCI_3

      Range
      89869..106263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011547768.1XP_011546070.1  

      See identical proteins and their annotated locations for XP_011546070.1

      UniProtKB/TrEMBL
      F1T0A5
      UniProtKB/Swiss-Prot
      Q8WWY3
      Conserved Domains (4) summary
      COG1498
      Location:76346
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam01798
      Location:190334
      Nop; Putative snoRNA binding domain
      pfam08060
      Location:93144
      NOSIC; NOSIC (NUC001) domain
      pfam09785
      Location:336465
      Prp31_C; Prp31 C terminal domain

    RNA

    1. XR_952757.1 RNA Sequence

    Reference GRCh38.p2 ALT_REF_LOCI_4

    Genomic

    1. NW_003571057.2 Reference GRCh38.p2 ALT_REF_LOCI_4

      Range
      89869..106263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011547971.1XP_011546273.1  

      See identical proteins and their annotated locations for XP_011546273.1

      UniProtKB/TrEMBL
      F1T0A5
      UniProtKB/Swiss-Prot
      Q8WWY3
      Conserved Domains (4) summary
      COG1498
      Location:76346
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam01798
      Location:190334
      Nop; Putative snoRNA binding domain
      pfam08060
      Location:93144
      NOSIC; NOSIC (NUC001) domain
      pfam09785
      Location:336465
      Prp31_C; Prp31 C terminal domain

    RNA

    1. XR_952909.1 RNA Sequence

    Reference GRCh38.p2 ALT_REF_LOCI_5

    Genomic

    1. NW_003571058.2 Reference GRCh38.p2 ALT_REF_LOCI_5

      Range
      89869..106263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011548148.1XP_011546450.1  

      See identical proteins and their annotated locations for XP_011546450.1

      UniProtKB/TrEMBL
      F1T0A5
      UniProtKB/Swiss-Prot
      Q8WWY3
      Conserved Domains (4) summary
      COG1498
      Location:76346
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam01798
      Location:190334
      Nop; Putative snoRNA binding domain
      pfam08060
      Location:93144
      NOSIC; NOSIC (NUC001) domain
      pfam09785
      Location:336465
      Prp31_C; Prp31 C terminal domain

    RNA

    1. XR_952987.1 RNA Sequence

    Reference GRCh38.p2 ALT_REF_LOCI_6

    Genomic

    1. NW_003571059.2 Reference GRCh38.p2 ALT_REF_LOCI_6

      Range
      89869..106263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011548341.1XP_011546643.1  

      See identical proteins and their annotated locations for XP_011546643.1

      UniProtKB/TrEMBL
      F1T0A5
      UniProtKB/Swiss-Prot
      Q8WWY3
      Conserved Domains (4) summary
      COG1498
      Location:76346
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam01798
      Location:190334
      Nop; Putative snoRNA binding domain
      pfam08060
      Location:93144
      NOSIC; NOSIC (NUC001) domain
      pfam09785
      Location:336465
      Prp31_C; Prp31 C terminal domain

    RNA

    1. XR_953061.1 RNA Sequence

    Reference GRCh38.p2 ALT_REF_LOCI_7

    Genomic

    1. NW_003571060.1 Reference GRCh38.p2 ALT_REF_LOCI_7

      Range
      89869..106263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006726309.2XP_006726372.1  

      See identical proteins and their annotated locations for XP_006726372.1

      UniProtKB/TrEMBL
      F1T0A5
      UniProtKB/Swiss-Prot
      Q8WWY3
      Conserved Domains (4) summary
      COG1498
      Location:76346
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam01798
      Location:190334
      Nop; Putative snoRNA binding domain
      pfam08060
      Location:93144
      NOSIC; NOSIC (NUC001) domain
      pfam09785
      Location:336465
      Prp31_C; Prp31 C terminal domain

    RNA

    1. XR_953130.1 RNA Sequence

    Reference GRCh38.p2 ALT_REF_LOCI_8

    Genomic

    1. NW_003571061.2 Reference GRCh38.p2 ALT_REF_LOCI_8

      Range
      89869..106263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011548606.1XP_011546908.1  

      See identical proteins and their annotated locations for XP_011546908.1

      UniProtKB/TrEMBL
      F1T0A5
      UniProtKB/Swiss-Prot
      Q8WWY3
      Conserved Domains (4) summary
      COG1498
      Location:76346
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam01798
      Location:190334
      Nop; Putative snoRNA binding domain
      pfam08060
      Location:93144
      NOSIC; NOSIC (NUC001) domain
      pfam09785
      Location:336465
      Prp31_C; Prp31 C terminal domain

    RNA

    1. XR_953148.1 RNA Sequence

    Reference GRCh38.p2 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p2 ALT_REF_LOCI_9

      Range
      89869..106263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006726193.2XP_006726256.1  

      See identical proteins and their annotated locations for XP_006726256.1

      UniProtKB/TrEMBL
      F1T0A5
      UniProtKB/Swiss-Prot
      Q8WWY3
      Conserved Domains (4) summary
      COG1498
      Location:76346
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam01798
      Location:190334
      Nop; Putative snoRNA binding domain
      pfam08060
      Location:93144
      NOSIC; NOSIC (NUC001) domain
      pfam09785
      Location:336465
      Prp31_C; Prp31 C terminal domain

    RNA

    1. XR_953171.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      54620429..54636738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)