Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    nfo endonuclease IV with intrinsic 3'-5' exonuclease activity [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946669, updated on 4-May-2016
    Gene symbol
    nfo
    Gene description
    endonuclease IV with intrinsic 3'-5' exonuclease activity
    Primary source
    EcoGene:EG10651
    Locus tag
    b2159
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2152; JW2146
    Summary
    Damaged bases in DNA occur due to alkylating agents, ionizing radiation or oxidants such as superoxide radicals, hydrogen peroxide and hydroxyl radicals. [More information is available at EcoCyc: EG10651].
    Sequence:
    NC_000913.3 (2250840..2251697)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative DNA-binding transcriptional regulator Neighboring gene UPF0324 family inner membrane protein Neighboring gene putative kinase Neighboring gene nucleoside permease

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Base excision repair, organism-specific biosystem (from KEGG)
      Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    • Base excision repair, conserved biosystem (from KEGG)
      Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    Products Interactant Other Gene Complex Source Pubs Description
    Names
    endonuclease IV with intrinsic 3'-5' exonuclease activity
    NP_416664.1
    • endonuclease IV

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2250840..2251697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416664.1 endonuclease IV with intrinsic 3'-5' exonuclease activity [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416664.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P0A6C1
      Conserved Domains (2) summary
      COG0648
      Location:1283
      Nfo; Endonuclease IV [Replication, recombination and repair]
      cd00019
      Location:4276
      AP2Ec; AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of ...