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    DPP4 dipeptidyl peptidase 4 [ Homo sapiens (human) ]

    Gene ID: 1803, updated on 25-Aug-2016
    Official Symbol
    DPP4provided by HGNC
    Official Full Name
    dipeptidyl peptidase 4provided by HGNC
    Primary source
    HGNC:HGNC:3009
    See related
    Ensembl:ENSG00000197635 HPRD:02187; MIM:102720; Vega:OTTHUMG00000132056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD26; ADABP; ADCP2; DPPIV; TP103
    Summary
    The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    2q24.3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (161992241..162074542, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (162848751..162931052, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 member 10 Neighboring gene uncharacterized LOC105373722 Neighboring gene ribulose-5-phosphate-3-epimerase pseudogene 5 Neighboring gene translocase of inner mitochondrial membrane 8 homolog A (yeast) pseudogene 1 Neighboring gene eukaryotic translation initiation factor 3 subunit E pseudogene 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    NHGRI GWA Catalog
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    NHGRI GWA Catalog
    Common variants at 12q14 and 12q24 are associated with hippocampal volume.
    NHGRI GWA Catalog
    Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of dipeptidyl-peptidase 4 (DPP4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env SDF-1alpha and HIV-1 gp120 induce the appearance of pseudopodia in which CD26 and CXCR4 co-localize PubMed
    env Infection of cells with Macrophage-tropic HIV-1 confers preferential survival to cells with low CD26 levels; the third hypervariable region (V3) of the HIV-1 gp120 envelope protein plays an important role in this selection process PubMed
    env Although CD26 has been described as a cofactor for HIV-1 gp120 mediated entry into cells, no evidence of a CD26-gp120 interaction was observed in vitro by using glutathione S-transferase-tagged HIV-1 gp120 PubMed
    env Apoptosis is observed in CD4+ cells expressing the HIV-1 gp120/gp41 complex and with enhanced levels of CD26, but is not detected in cell lines expressing an uncleavable precursor of HIV-1 gp160 PubMed
    env CD26 (dipeptidyl peptidase IV) cleaves the highly conserved V3 loop of HIV-1 gp120 and functions as a cofactor for entry of HIV-1 in CD4+ human cells; coexpression of human CD4 and CD26 in murine NIH 3T3 cells renders them permissive to HIV-1 PubMed
    env HIV-1 gp120 inhibits adenosine deaminase (ADA) binding to CD26 (dipeptidyl-peptidase 4) in both CD4+ and CD4- cells; this effect requires the interaction of gp120 with CD4 or CXCR4 PubMed
    env Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC PubMed
    Envelope transmembrane glycoprotein gp41 env Apoptosis is observed in CD4+ cells expressing the HIV-1 gp120/gp41 complex and with enhanced levels of CD26, but is not detected in cell lines expressing an uncleavable precursor of HIV-1 gp160 PubMed
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of dipeptidylpeptidase 4 (DPP4; CD26; adenosine deaminase complexing protein 2) in primary human brain microvascular endothelial cells PubMed
    tat HIV-1 Tat induces tyrosine phosphorylation of DPPIV in Tat/DPPIV-coexpressing cells PubMed
    tat HIV1-Tat co-localizes and coimmunoprecipitates with human Dipeptidyl peptidase IV (DPPIV) protein PubMed
    tat The N-terminal nine amino acids of HIV-1 Tat mediate the binding of Tat to CD26 PubMed
    tat HIV-1 Tat inhibits the enzymatic activity of CD26, thereby suppressing DNA synthesis and IL-1 beta production, stimulating secretion of IL-1 receptor antagonist and TNF-alpha, and causing, at least in part, the immunosuppressive effects of Tat PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    dipeptidyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    virus receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    T cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    locomotory exploration behavior IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of extracellular matrix disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    psychomotor behavior IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell-cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intercellular canaliculus IEA
    Inferred from Electronic Annotation
    more info
     
    invadopodium membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    dipeptidyl peptidase 4
    Names
    ADCP-2
    DPP IV
    T-cell activation antigen CD26
    adenosine deaminase complexing protein 2
    dipeptidyl peptidase IV
    dipeptidyl-peptidase 4
    dipeptidylpeptidase 4
    dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
    NP_001926.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001935.3NP_001926.2  dipeptidyl peptidase 4

      See identical proteins and their annotated locations for NP_001926.2

      Status: REVIEWED

      Source sequence(s)
      BC065265
      Consensus CDS
      CCDS2216.1
      UniProtKB/Swiss-Prot
      P27487
      Related
      ENSP00000353731, OTTHUMP00000162936, ENST00000360534, OTTHUMT00000255079
      Conserved Domains (3) summary
      COG1506
      Location:398764
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:559763
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:108478
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      161992241..162074542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005246371.2XP_005246428.1  

      Conserved Domains (3) summary
      COG1506
      Location:397763
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:558762
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:107477
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      162854656..162936956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)