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    App amyloid beta (A4) precursor protein [ Mus musculus (house mouse) ]

    Gene ID: 11820, updated on 23-Aug-2016
    Official Symbol
    Appprovided by MGI
    Official Full Name
    amyloid beta (A4) precursor proteinprovided by MGI
    Primary source
    MGI:MGI:88059
    See related
    Ensembl:ENSMUSG00000022892
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ag; Abpp; Adap; Cvap; Abeta; betaApp; E030013M08Rik
    Orthologs
    Location:
    16 46.92 cM; 16 C3-qter
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (84952666..85173952, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (84954688..85173948, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108168296 Neighboring gene junction adhesion molecule 2 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F Neighboring gene GA repeat binding protein, alpha Neighboring gene predicted gene 10791 Neighboring gene predicted gene, 41482 Neighboring gene predicted gene, 41483

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    PTB domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    axo-dendritic transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    axo-dendritic transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT axo-dendritic transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon midline choice point recognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular copper ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to norepinephrine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    collateral sprouting in absence of injury IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dendrite development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    extracellular matrix organization IGI
    Inferred from Genetic Interaction
    more info
     
    forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ionotropic glutamate receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mRNA polyadenylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mating behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular process controlling balance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
     
    positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of epidermal growth factor-activated receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synapse structure or activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    smooth endoplasmic reticulum calcium ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    suckling behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    synaptic growth at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    apical part of cell IDA
    Inferred from Direct Assay
    more info
     
    astrocyte projection ISO
    Inferred from Sequence Orthology
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ciliary rootlet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    main axon ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope lumen ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    spindle midzone IDA
    Inferred from Direct Assay
    more info
     
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    amyloid beta A4 protein
    Names
    alzheimer disease amyloid A4 protein homolog
    amyloid precursor protein
    amyloidogenic glycoprotein
    appican
    beta-amyloid precursor protein
    protease nexin II

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198823.1NP_001185752.1  amyloid beta A4 protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_001185752.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK128971, AK159718, BC070409, BP753972
      UniProtKB/Swiss-Prot
      P12023
      UniProtKB/TrEMBL
      Q3TWF3, Q6GR78
      Conserved Domains (7) summary
      pfam03494
      Location:682713
      Beta-APP; Beta-amyloid peptide (beta-APP)
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam12924
      Location:132188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      cd00109
      Location:295342
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam02177
      Location:30131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:715766
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:365549
      APP_E2; E2 domain of amyloid precursor protein
    2. NM_001198824.1NP_001185753.1  amyloid beta A4 protein isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK128971, AK133639, BC070409, BP753972
      UniProtKB/TrEMBL
      Q6GR78
      Conserved Domains (7) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:656694
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:697747
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:347529
      APP_E2; E2 domain of amyloid precursor protein
    3. NM_001198825.1NP_001185754.1  amyloid beta A4 protein isoform 5 precursor

      Status: VALIDATED

      Description
      Transcript Variant: Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK128971, AK133639, BC070409, BP753972
      UniProtKB/TrEMBL
      Q6GR78
      Conserved Domains (7) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:638676
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:679729
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:347529
      APP_E2; E2 domain of amyloid precursor protein
    4. NM_001198826.1NP_001185755.1  amyloid beta A4 protein isoform 6 precursor

      See identical proteins and their annotated locations for NP_001185755.1

      Status: VALIDATED

      Description
      Transcript Variant: Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK128971, AK159718, BC070409, BP753972
      UniProtKB/TrEMBL
      Q3TWF3, Q6GR78
      Conserved Domains (7) summary
      pfam03494
      Location:664695
      Beta-APP; Beta-amyloid peptide (beta-APP)
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam12924
      Location:132188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      cd00109
      Location:295342
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam02177
      Location:30131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:697748
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:365549
      APP_E2; E2 domain of amyloid precursor protein
    5. NM_007471.3NP_031497.2  amyloid beta A4 protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_031497.2

      Status: VALIDATED

      Description
      Transcript Variant: Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK128971, BC070409, BP753972
      Consensus CDS
      CCDS28285.1
      UniProtKB/TrEMBL
      Q6GR78
      Related
      ENSMUSP00000005406, ENSMUST00000005406
      Conserved Domains (6) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:600638
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:641691
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:291473
      APP_E2; E2 domain of amyloid precursor protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      84952666..85173952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522873.2XP_006522936.1  

      Conserved Domains (6) summary
      pfam03494
      Location:589620
      Beta-APP; Beta-amyloid peptide (beta-APP)
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam12924
      Location:132188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam02177
      Location:30131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:622673
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:290474
      APP_E2; E2 domain of amyloid precursor protein
    2. XM_006522874.1XP_006522937.1  

      Conserved Domains (5) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam12924
      Location:132188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      cd00109
      Location:295342
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam02177
      Location:30131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam12925
      Location:365549
      APP_E2; E2 domain of amyloid precursor protein