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COMT catechol-O-methyltransferase [ Homo sapiens (human) ]

Gene ID: 1312, updated on 26-Aug-2014
Official Symbol
COMTprovided by HGNC
Official Full Name
catechol-O-methyltransferaseprovided by HGNC
Primary source
HGNC:2228
See related
Ensembl:ENSG00000093010; HPRD:00284; MIM:116790; Vega:OTTHUMG00000150529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEL-S-98n
Summary
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
See COMT in Epigenomics, MapViewer
Location:
22q11.21
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 22 NC_000022.11 (19941740..19969975)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (19929263..19957498)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene thioredoxin reductase 2 Neighboring gene KIAA1652 protein Neighboring gene ribosomal protein L8 pseudogene 5 Neighboring gene microRNA 4761 Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome Neighboring gene transport and golgi organization 2 homolog (Drosophila) Neighboring gene microRNA 185 Neighboring gene microRNA 3618 Neighboring gene DGCR8 microprocessor complex subunit

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with catechol-O-methyltransferase (COMT) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Biogenic Amine Synthesis, organism-specific biosystem (from WikiPathways)
    Biogenic Amine Synthesis, organism-specific biosystemBiogenic amines are one of two broad classes of classical neurotransmitters (the other being amino acids) and include: acetylcholine, serotonin, histamine, and the catecholamines epinephrine, norepin...
  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Dopamine clearance from the synaptic cleft, organism-specific biosystem (from REACTOME)
    Dopamine clearance from the synaptic cleft, organism-specific biosystemThe human gene SLC6A3 encodes the sodium-dependent dopamine transporter, DAT which mediates the re-uptake of dopamine from the synaptic cleft (Vandenbergh DJ et al, 2000). Dopamine can then be degrad...
  • Dopamine metabolism, organism-specific biosystem (from WikiPathways)
    Dopamine metabolism, organism-specific biosystem
    Dopamine metabolism
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Enzymatic degradation of Dopamine by monoamine oxidase, organism-specific biosystem (from REACTOME)
    Enzymatic degradation of Dopamine by monoamine oxidase, organism-specific biosystemAlternately dopamine is metabolized to homovanillic acid in a two-step reaction in which dopamine is first oxidized to 3,4-dihydroxypheylacetic acid (DOPAC) and then converted to homovanillic acid by...
  • Enzymatic degradation of dopamine by COMT, organism-specific biosystem (from REACTOME)
    Enzymatic degradation of dopamine by COMT, organism-specific biosystemDopamine once taken up by the dopamine transporter from the extracellular space into the cytosol is metabolized in a two step reaction to homovanillic acid.The first reaction is catalyzed by catechol...
  • Estrogen metabolism, organism-specific biosystem (from WikiPathways)
    Estrogen metabolism, organism-specific biosystem
    Estrogen metabolism
  • L-dopa degradation, organism-specific biosystem (from BIOCYC)
    L-dopa degradation, organism-specific biosystemGeneral Background The major pathway of : L-DIHYDROXY-PHENYLALANINE metabolism involves its role as a precursor metabolite in the biosynthesis of the catecholamines : DOPAMINE, : NOREPINEPHRINE and ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Methylation, organism-specific biosystem (from REACTOME)
    Methylation, organism-specific biosystemMethylation is a common but minor pathway of Phase II conjugation compared to glucuronidation or sulfonation. The cofactor used in methylation conjugation is S-adenosylmethionine (SAM). SAM is the ...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Neurotransmitter Clearance In The Synaptic Cleft, organism-specific biosystem (from REACTOME)
    Neurotransmitter Clearance In The Synaptic Cleft, organism-specific biosystemNeurotransmitter released in the synaptic cleft binds to specific receptors on the post-synaptic cell and the excess of the neurotransmitter is cleared to prevent over activation of the post-synapti...
  • Phase II conjugation, organism-specific biosystem (from REACTOME)
    Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
  • Steroid hormone biosynthesis, organism-specific biosystem (from KEGG)
    Steroid hormone biosynthesis, organism-specific biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...
  • Steroid hormone biosynthesis, conserved biosystem (from KEGG)
    Steroid hormone biosynthesis, conserved biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
  • Tyrosine metabolism, organism-specific biosystem (from KEGG)
    Tyrosine metabolism, organism-specific biosystem
    Tyrosine metabolism
  • Tyrosine metabolism, conserved biosystem (from KEGG)
    Tyrosine metabolism, conserved biosystem
    Tyrosine metabolism
  • dopamine degradation, organism-specific biosystem (from BIOCYC)
    dopamine degradation, organism-specific biosystemThe catecholamines dopamine, noradrenaline (norepinephrine), and adrenaline (epinephrine) function as neurotransmitters and hormones. They have important physiological regulatory roles and are invo...
  • dopamine degradation, conserved biosystem (from BIOCYC)
    dopamine degradation, conserved biosystemThe catecholamines dopamine, noradrenaline (norepinephrine), and adrenaline (epinephrine) function as neurotransmitters and hormones. They have important physiological regulatory roles and are invo...
  • metapathway biotransformation, organism-specific biosystem (from WikiPathways)
    metapathway biotransformation, organism-specific biosystem
    metapathway biotransformation
  • noradrenaline and adrenaline degradation, organism-specific biosystem (from BIOCYC)
    noradrenaline and adrenaline degradation, organism-specific biosystemGeneral Background The catecholamines : DOPAMINE, : NOREPINEPHRINE (norepinephrine), and : L-EPINEPHRINE (epinephrine) function as neurotransmitters and hormones. They have important physiological ...
  • noradrenaline and adrenaline degradation, conserved biosystem (from BIOCYC)
    noradrenaline and adrenaline degradation, conserved biosystemGeneral Background The catecholamines |FRAME: DOPAMINE|, |FRAME: NOREPINEPHRINE| (norepinephrine), and |FRAME: L-EPINEPHRINE| (epinephrine) function as neurotransmitters and hormones. They have imp...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
O-methyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
catechol O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
dopamine catabolic process IEA
Inferred from Electronic Annotation
more info
 
estrogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
learning IEA
Inferred from Electronic Annotation
more info
 
methylation TAS
Traceable Author Statement
more info
 
multicellular organismal reproductive process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dopamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter biosynthetic process TAS
Traceable Author Statement
more info
 
neurotransmitter catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of homocysteine metabolic process IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
response to pain IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
synaptic transmission TAS
Traceable Author Statement
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
catechol O-methyltransferase
Names
catechol O-methyltransferase
epididymis secretory sperm binding protein Li 98n
NP_000745.1
NP_001128633.1
NP_001128634.1
NP_009294.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011526.1 

    Range
    5001..33236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000754.3NP_000745.1  catechol O-methyltransferase isoform MB-COMT

    See proteins identical to NP_000745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as MB-COMT) represents the longest transcript and encodes the longer isoform (MB-COMT). Variants 1, 2, and 3 all encode isoform MB-COMT and may also make the shorter isoform S-COMT at a low level. MB-COMT is a membrane-bound protein.
    Source sequence(s)
    AC005663, AK290440, BX461394
    Consensus CDS
    CCDS13770.1
    UniProtKB/Swiss-Prot
    P21964
    Related
    ENSP00000354511, OTTHUMP00000197846, ENST00000361682, OTTHUMT00000318936
    Conserved Domains (1) summary
    cd02440
    Location:112217
    Blast Score: 114
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001135161.1NP_001128633.1  catechol O-methyltransferase isoform MB-COMT

    See proteins identical to NP_001128633.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform MB-COMT and may also make the shorter isoform S-COMT at a low level. MB-COMT is a membrane-bound protein.
    Source sequence(s)
    AC005663, AK290440, BE386545
    Consensus CDS
    CCDS13770.1
    UniProtKB/Swiss-Prot
    P21964
    Conserved Domains (1) summary
    cd02440
    Location:112217
    Blast Score: 114
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_001135162.1NP_001128634.1  catechol O-methyltransferase isoform MB-COMT

    See proteins identical to NP_001128634.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform MB-COMT and may also make the shorter isoform S-COMT at a low level. MB-COMT is a membrane-bound protein.
    Source sequence(s)
    AC005663, AK290440, BE728779
    Consensus CDS
    CCDS13770.1
    UniProtKB/Swiss-Prot
    P21964
    Conserved Domains (1) summary
    cd02440
    Location:112217
    Blast Score: 114
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. NM_007310.2NP_009294.1  catechol O-methyltransferase isoform S-COMT

    See proteins identical to NP_009294.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as S-COMT) contains a shorter 5' UTR and a translation start site which lies 50 codons downstream compared to that of variant 1. The resulting isoform (S-COMT) is shorter at the N-terminus compared to isoform MB-COMT. S-COMT is a soluble protein.
    Source sequence(s)
    AC005663, AK290440
    Consensus CDS
    CCDS46663.1
    UniProtKB/Swiss-Prot
    P21964
    Conserved Domains (1) summary
    cd02440
    Location:62167
    Blast Score: 113
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000022.11 

    Range
    19941740..19969975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261229.1XP_005261286.1  

    See proteins identical to XP_005261286.1

    UniProtKB/Swiss-Prot
    P21964
    Related
    ENSP00000385917, OTTHUMP00000197749, ENST00000403710, OTTHUMT00000318771
    Conserved Domains (1) summary
    cd02440
    Location:112217
    Blast Score: 114
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

Alternate HuRef

Genomic

  1. AC_000154.1 

    Range
    3549825..3577976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 

    Range
    19929027..19957208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)