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ADIPOQ adiponectin, C1Q and collagen domain containing [ Homo sapiens (human) ]

Gene ID: 9370, updated on 7-Jul-2014
Official Symbol
ADIPOQprovided by HGNC
Official Full Name
adiponectin, C1Q and collagen domain containingprovided by HGNC
Primary source
HGNC:13633
See related
Ensembl:ENSG00000181092; HPRD:05671; MIM:605441; Vega:OTTHUMG00000156521
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1
Summary
This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
See ADIPOQ in Epigenomics, MapViewer
Location:
3q27
Exon count :
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (186842674..186858463)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (186560463..186576252)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 Neighboring gene replication factor C (activator 1) 4, 37kDa Neighboring gene uncharacterized LOC102724699 Neighboring gene ADIPOQ antisense RNA 1 Neighboring gene ribosomal protein S20 pseudogene 14 Neighboring gene ribosomal protein L29 pseudogene 9

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Serum level of adiponectin 1
MedGen: C2675517 OMIM: 612556 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.
NHGRI GWA Catalog
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
NHGRI GWA Catalog
Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals.
NHGRI GWA Catalog
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
NHGRI GWA Catalog
Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ.
NHGRI GWA Catalog
Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study.
NHGRI GWA Catalog
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
NHGRI GWA Catalog
Novel locus FER is associated with serum HMW adiponectin levels.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat HIV-1 Tat downregulates the expression of adiponectin protein and upregulates the expression of IL-6, IL-8, and MCP-1 proteins in human SGBS preadipocytes PubMed

Go to the HIV-1, Human Protein Interaction Database

  • AMPK signaling, organism-specific biosystem (from WikiPathways)
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  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
    Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
    Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
  • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
    Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
  • Type II diabetes mellitus, organism-specific biosystem (from WikiPathways)
    Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
  • Type II diabetes mellitus, conserved biosystem (from KEGG)
    Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity NAS
Non-traceable Author Statement
more info
PubMed 
hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
sialic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
adiponectin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
cellular response to drug ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to epinephrine stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
detection of oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
low-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
membrane depolarization IEA
Inferred from Electronic Annotation
more info
 
membrane hyperpolarization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of granulocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of heterotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of hormone secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of intracellular protein transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of low-density lipoprotein particle receptor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of macrophage derived foam cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of macrophage differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of metanephric mesenchymal cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of platelet-derived growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cellular protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of glucose import ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of glycogen (starch) synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of metanephric glomerular visceral epithelial cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of monocyte chemotactic protein-1 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of myeloid cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase A signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of renal albumin absorption IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein heterotrimerization IEA
Inferred from Electronic Annotation
more info
 
protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
regulation of glucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
response to activity IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to glucose ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to linoleic acid IEA
Inferred from Electronic Annotation
more info
 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
response to sucrose IEA
Inferred from Electronic Annotation
more info
 
response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
collagen trimer IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
Preferred Names
adiponectin
Names
adiponectin
gelatin-binding protein 28
adipose specific collagen-like factor
30 kDa adipocyte complement-related protein
adipocyte complement-related 30 kDa protein
adipose most abundant gene transcript 1 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021140.1 

    Range
    5001..20790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177800.1NP_001171271.1  adiponectin precursor

    See proteins identical to NP_001171271.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC072018, AC112907, AK312868
    Consensus CDS
    CCDS3284.1
    UniProtKB/TrEMBL
    A8K660
    UniProtKB/TrEMBL
    B2R773
    UniProtKB/Swiss-Prot
    Q15848
    Related
    ENSP00000389814, OTTHUMP00000210047, ENST00000444204, OTTHUMT00000344489
    Conserved Domains (2) summary
    smart00110
    Location:106242
    Blast Score: 498
    C1Q; Complement component C1q domain
    pfam01391
    Location:42106
    Blast Score: 137
    Collagen; Collagen triple helix repeat (20 copies)
  2. NM_004797.3NP_004788.1  adiponectin precursor

    See proteins identical to NP_004788.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC072018, AC112907, AK291525, BC096308
    Consensus CDS
    CCDS3284.1
    UniProtKB/TrEMBL
    A8K660
    UniProtKB/Swiss-Prot
    Q15848
    Related
    ENSP00000320709, OTTHUMP00000210048, ENST00000320741, OTTHUMT00000344490
    Conserved Domains (2) summary
    smart00110
    Location:106242
    Blast Score: 498
    C1Q; Complement component C1q domain
    pfam01391
    Location:42106
    Blast Score: 137
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    186842674..186858463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    183969546..183985186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    186523992..186539778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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