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    ENO1 enolase 1 [ Homo sapiens (human) ]

    Gene ID: 2023, updated on 14-Apr-2016
    Official Symbol
    ENO1provided by HGNC
    Official Full Name
    enolase 1provided by HGNC
    Primary source
    HGNC:HGNC:3350
    See related
    Ensembl:ENSG00000074800 HPRD:01400; MIM:172430; Vega:OTTHUMG00000001773
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NNE; PPH; MPB1; ENO1L1; HEL-S-17
    Summary
    This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]
    Orthologs
    Location:
    1p36.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (8861000..8879092, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (8921059..8939151, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene arginine-glutamic acid dipeptide repeats Neighboring gene ribosomal protein L27 pseudogene Neighboring gene ribosomal protein L23a pseudogene 19 Neighboring gene microRNA 6728 Neighboring gene uncharacterized LOC105376696 Neighboring gene ENO1 antisense RNA 1 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 17

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify alpha unit of enolase 1 (ENO1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify alpha unit of enolase 1 (ENO1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef HIV-1 Nef downregulates the expression of enolase 1 (ENO1) protein in Nef-transfected SupT1 cells PubMed
    nef Tandem affinity purification and mass spectrometry analysis identify alpha unit of enolase 1 (ENO1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify alpha unit of enolase 1 (ENO1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Tat tat MBP-1 suppresses transcription from the HIV-1 LTR promoter, an effect that is inhibited by HIV-1 Tat, suggesting an important role for MBP-1 in the regulation of HIV-1 replication in infected cells PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human enolase 1, alpha (ENO1) at amino acid residues 115-116 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphopyruvate hydratase activity TAS
    Traceable Author Statement
    more info
     
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription corepressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    canonical glycolysis TAS
    Traceable Author Statement
    more info
     
    gluconeogenesis TAS
    Traceable Author Statement
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of binding IEA
    Inferred from Electronic Annotation
    more info
     
    response to virus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    M band IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IC
    Inferred by Curator
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphopyruvate hydratase complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    alpha-enolase; c-myc promoter-binding protein-1
    Names
    2-phospho-D-glycerate hydro-lyase
    MYC promoter-binding protein 1
    alpha enolase like 1
    enolase 1, (alpha)
    enolase-alpha
    epididymis secretory protein Li 17
    non-neural enolase
    phosphopyruvate hydratase
    plasminogen-binding protein
    tau-crystallin
    NP_001188412.1
    NP_001419.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029470.1 RefSeqGene

      Range
      5001..23093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201483.1NP_001188412.1  c-myc promoter-binding protein-1 isoform MBP-1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs at the 5' end compared to variant 1, and initiates translation from an in-frame downstream start codon, resulting in a shorter isoform (MBP-1). This isoform is localized to the nucleus, and functions as a transcriptional repressor of c-myc protooncogene by binding to its promoter (PMID:20849415).
      Source sequence(s)
      BC021166, GU170215
      UniProtKB/Swiss-Prot
      P06733
      UniProtKB/TrEMBL
      E2DRY6
      Conserved Domains (2) summary
      pfam00113
      Location:49339
      Enolase_C; Enolase, C-terminal TIM barrel domain
      cd03313
      Location:1323
      enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.
    2. NM_001428.3NP_001419.1  alpha-enolase isoform 1

      See identical proteins and their annotated locations for NP_001419.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1), which is localized to the cytosol, and has alpha-enolase activity. It has been reported that the monomeric form of this isoform functions as a structural lens protein (tau-crystallin), and the dimeric form as an enolase (PMID:2462567).
      Source sequence(s)
      AK309177, BC021166
      Consensus CDS
      CCDS97.1
      UniProtKB/Swiss-Prot
      P06733
      UniProtKB/TrEMBL
      A0A024R4F1
      Related
      ENSP00000234590, OTTHUMP00000001706, ENST00000234590, OTTHUMT00000004945
      Conserved Domains (2) summary
      PLN00191
      Location:2432
      PLN00191; enolase
      cd03313
      Location:5416
      enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

      Range
      8861000..8879092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006710433.1XP_006710496.1  

      Conserved Domains (2) summary
      PLN00191
      Location:2432
      PLN00191; enolase
      cd03313
      Location:5416
      enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      8910955..8929047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)