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CD24 CD24 molecule [ Homo sapiens (human) ]

Gene ID: 100133941, updated on 21-May-2015
Official Symbol
CD24provided by HGNC
Official Full Name
CD24 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1645
See related
Ensembl:ENSG00000272398; MIM:600074; Vega:OTTHUMG00000188439
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD24A
Summary
This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Orthologs
See CD24 in MapViewer
Location:
6q21
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (106969831..106976855, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 (PATCHES) NW_004504300.1 (274454..280365, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377928 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 12 Neighboring gene chromosome 6 open reading frame 203 Neighboring gene BEN domain containing 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • L1CAM interactions, organism-specific biosystem (from REACTOME)
    L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ22950, FLJ43543, MGC75043

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
signal transducer activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
B cell receptor transport into membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
T cell costimulation IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
axon guidance TAS
Traceable Author Statement
more info
 
cell activation IDA
Inferred from Direct Assay
more info
PubMed 
cell migration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
chemokine receptor transport out of membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
glomerular parietal epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
glomerular visceral epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response-regulating cell surface receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
intrinsic apoptotic signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of transforming growth factor beta3 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of activated T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nephron tubule epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of epithelial cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
respiratory burst IDA
Inferred from Direct Assay
more info
PubMed 
response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to molecule of bacterial origin ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
single organismal cell-cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
intracellular ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
signal transducer CD24
Names
signal transducer CD24
CD24 antigen (small cell lung carcinoma cluster 4 antigen)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041768.1 RefSeqGene

    Range
    5001..12025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001291737.1NP_001278666.1  signal transducer CD24 isoform a preproprotein

    See identical proteins and their annotated locations for NP_001278666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode isoform a.
    Source sequence(s)
    AK026603, AK125531, AU125939, BU580553, DA753855
    Consensus CDS
    CCDS75499.1
    UniProtKB/TrEMBL
    B6EC88
    UniProtKB/Swiss-Prot
    P25063
    Conserved Domains (1) summary
    pfam14984
    Location:4779
    CD24; CD24 protein
  2. NM_001291738.1NP_001278667.1  signal transducer CD24 isoform a preproprotein

    See identical proteins and their annotated locations for NP_001278667.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode isoform a.
    Source sequence(s)
    AK026603, AK125531, BU580553, DA378105
    Consensus CDS
    CCDS75499.1
    UniProtKB/TrEMBL
    B6EC88
    UniProtKB/Swiss-Prot
    P25063
    Conserved Domains (1) summary
    pfam14984
    Location:4779
    CD24; CD24 protein
  3. NM_001291739.1NP_001278668.1  signal transducer CD24 isoform b

    See identical proteins and their annotated locations for NP_001278668.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AK026603, AK125531, BU580553, DA518957
    Consensus CDS
    CCDS78166.1
    UniProtKB/TrEMBL
    A0A087WYI6
    Conserved Domains (1) summary
    pfam14984
    Location:96128
    CD24; CD24 protein
  4. NM_013230.3NP_037362.1  signal transducer CD24 isoform a preproprotein

    See identical proteins and their annotated locations for NP_037362.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode isoform a.
    Source sequence(s)
    AK026603, AK125531, BG755979, BU580553
    Consensus CDS
    CCDS75499.1
    UniProtKB/TrEMBL
    B6EC88
    UniProtKB/Swiss-Prot
    P25063
    Related
    ENSP00000483985, OTTHUMP00000276593, ENST00000619133, OTTHUMT00000477241
    Conserved Domains (1) summary
    pfam14984
    Location:4779
    CD24; CD24 protein

RNA

  1. NR_117089.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks the internal exon and contains an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.
    Source sequence(s)
    AK026603, AK125531, AU125939, BU580553, DA745135
  2. NR_117090.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks the internal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.
    Source sequence(s)
    AK026603, AK125531, BG755979, BU580553, DA253943

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    106969831..106976855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535375.1XP_011533677.1