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IL22 interleukin 22 [ Homo sapiens (human) ]

Gene ID: 50616, updated on 19-Jul-2014
Official Symbol
IL22provided by HGNC
Official Full Name
interleukin 22provided by HGNC
Primary source
HGNC:14900
Locus tag
UNQ3099/PRO10096
See related
Ensembl:ENSG00000127318; HPRD:05621; MIM:605330; Vega:OTTHUMG00000169119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23
Annotation information
Note: This gene (GeneID: 50616) was identified as IL-21 or IL-TIF in PMID: 10954742. The official symbol for this gene is now IL22. [19 May 2011]
See IL22 in Epigenomics, MapViewer
Location:
12q15
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (68248245..68253599, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (68642025..68647379, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene interferon, gamma Neighboring gene interleukin 26 Neighboring gene Mdm1 nuclear protein homolog (mouse) Neighboring gene uncharacterized LOC100507195

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
NHGRI GWA Catalog
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
    Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
    Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC79382, MGC79384

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-22 receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acute-phase response NAS
Non-traceable Author Statement
more info
PubMed 
cell-cell signaling IC
Inferred by Curator
more info
PubMed 
inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IC
Inferred by Curator
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
interleukin-22
Names
interleukin-22
cytokine Zcyto18
IL-10-related T-cell-derived inducible factor
IL-10-related T-cell-derived-inducible factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020525.4NP_065386.1  interleukin-22 precursor

    See proteins identical to NP_065386.1

    Status: VALIDATED

    Source sequence(s)
    AY358890, CD559617
    Consensus CDS
    CCDS8982.1
    UniProtKB/Swiss-Prot
    Q9GZX6
    Related
    ENSP00000329384, ENST00000328087
    Conserved Domains (1) summary
    pfam14565
    Location:40178
    Blast Score: 703
    IL22; Interleukin 22 IL-10-related T-cell-derived-inducible factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    68248245..68253599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268929.1XP_005268986.1  

    See proteins identical to XP_005268986.1

    UniProtKB/Swiss-Prot
    Q9GZX6
    Related
    ENSP00000442424, OTTHUMP00000240117, ENST00000538666, OTTHUMT00000402318
    Conserved Domains (1) summary
    pfam14565
    Location:40178
    Blast Score: 703
    IL22; Interleukin 22 IL-10-related T-cell-derived-inducible factor

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    65693180..65698437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    68610008..68615263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)