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    Cdk4 cyclin-dependent kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 12567, updated on 19-Jul-2016
    Official Symbol
    Cdk4provided by MGI
    Official Full Name
    cyclin-dependent kinase 4provided by MGI
    Primary source
    MGI:MGI:88357
    See related
    Ensembl:ENSMUSG00000006728 Vega:OTTMUSG00000030604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crk3
    Orthologs
    Location:
    10; 10 D3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (127063535..127067288)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (126500659..126504339)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 27, subfamily b, polypeptide 1 Neighboring gene membrane-associated ring finger (C3HC4) 9 Neighboring gene tetraspanin 31 Neighboring gene RIKEN cDNA A730063M14 gene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Targeted (8)  1 citation
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to lead ion ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    response to testosterone ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin D2-CDK4 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    cyclin-dependent kinase 4
    Names
    PSK-J3
    cell division protein kinase 4
    cyclin dependent kinase 4
    p34<PSK-J3>/cdk4
    serine/threonine kinase
    NP_034000.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009870.3NP_034000.1  cyclin-dependent kinase 4

      See identical proteins and their annotated locations for NP_034000.1

      Status: VALIDATED

      Source sequence(s)
      BC046336
      Consensus CDS
      CCDS24226.1
      UniProtKB/Swiss-Prot
      P30285
      UniProtKB/TrEMBL
      Q545C3
      Related
      ENSMUSP00000006911, OTTMUSP00000039796, ENSMUST00000006911, OTTMUST00000075793
      Conserved Domains (2) summary
      cd07863
      Location:5295
      STKc_CDK4; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4
      smart00220
      Location:6295
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      127063535..127067288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513163.3XP_006513226.1  

      Conserved Domains (2) summary
      smart00220
      Location:12221
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1221
      PKc_like; Protein Kinases, catalytic domain