Display Settings:

Format

Send to:

Choose Destination

Nefm neurofilament, medium polypeptide [ Mus musculus (house mouse) ]

Gene ID: 18040, updated on 13-Aug-2014
Official Symbol
Nefmprovided by MGI
Official Full Name
neurofilament, medium polypeptideprovided by MGI
Primary source
MGI:97314
See related
Ensembl:ENSMUSG00000022054; Vega:OTTMUSG00000016378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nfm; NF-M; Nef3; NF160; NF165
See Nefm in Epigenomics, MapViewer
Location:
14 D1; 14
Exon count:
3
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 14 NC_000080.6 (68119545..68125004, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A230070E04 gene Neighboring gene neurofilament, light polypeptide Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 pseudogene Neighboring gene uncharacterized LOC102633392 Neighboring gene a disintegrin and metallopeptidase domain 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
    Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
  • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
    Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
axon cargo transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
intermediate filament bundle assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
intermediate filament cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
neurofilament cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
neurofilament cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of axon diameter IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 
intracellular IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurofilament IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
 
Preferred Names
neurofilament medium polypeptide
Names
neurofilament medium polypeptide
neurofilament-M
neurofilament 3, medium
neurofilament protein M
160 kDa neurofilament protein
neurofilament triplet M protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008691.2NP_032717.2  neurofilament medium polypeptide

    See proteins identical to NP_032717.2

    Status: VALIDATED

    Source sequence(s)
    AC154687, AK051696, BE986344, BF466963
    Consensus CDS
    CCDS27233.1
    UniProtKB/Swiss-Prot
    P08553
    Related
    ENSMUSP00000022638, OTTMUSP00000017611, ENSMUST00000022638, OTTMUST00000039418
    Conserved Domains (2) summary
    pfam00038
    Location:98409
    Blast Score: 976
    Filament; Intermediate filament protein
    pfam04732
    Location:1072
    Blast Score: 137
    Filament_head; Intermediate filament head (DNA binding) region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000080.6 

    Range
    68119545..68125004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000036.1 

    Range
    65887284..65892688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)