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PRC1 protein regulator of cytokinesis 1 [ Homo sapiens (human) ]

Gene ID: 9055, updated on 23-Sep-2014
Official Symbol
PRC1provided by HGNC
Official Full Name
protein regulator of cytokinesis 1provided by HGNC
Primary source
HGNC:HGNC:9341
See related
Ensembl:ENSG00000198901; HPRD:17899; MIM:603484; Vega:OTTHUMG00000171685
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASE1
Summary
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
See PRC1 in Epigenomics, MapViewer
Location:
15q26.1
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (90966038..90994651, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91509268..91537881, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene mannosidase, alpha, class 2A, member 2 Neighboring gene unc-45 homolog A (C. elegans) Neighboring gene HD domain containing 3 Neighboring gene RCC1 domain containing 1 Neighboring gene PRC1 antisense RNA 1 Neighboring gene vacuolar protein sorting 33 homolog B (yeast) Neighboring gene uncharacterized LOC101926911

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC1671, MGC3669

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cytokinesis IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle elongation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
spindle IDA
Inferred from Direct Assay
more info
PubMed 
spindle microtubule TAS
Traceable Author Statement
more info
PubMed 
spindle pole IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein regulator of cytokinesis 1
Names
protein regulator of cytokinesis 1
protein regulating cytokinesis 1
anaphase spindle elongation 1 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267580.1NP_001254509.1  protein regulator of cytokinesis 1 isoform 4

    See proteins identical to NP_001254509.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and uses and alternate splice site and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC068831, AK297117, BX647317, DA655494, DW423775
    Consensus CDS
    CCDS45353.2
    UniProtKB/Swiss-Prot
    O43663
    Conserved Domains (2) summary
    pfam03999
    Location:34523
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:219370
    Glyco_hydro_77; 4-alpha-glucanotransferase
  2. NM_003981.3NP_003972.1  protein regulator of cytokinesis 1 isoform 1

    See proteins identical to NP_003972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF044588, BC003138, BX647317, DA655494, DW423775
    Consensus CDS
    CCDS32334.1
    UniProtKB/TrEMBL
    A0A024RC67
    UniProtKB/Swiss-Prot
    O43663
    Related
    ENSP00000377793, OTTHUMP00000246702, ENST00000394249, OTTHUMT00000414757
    Conserved Domains (2) summary
    pfam03999
    Location:37615
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  3. NM_199413.2NP_955445.1  protein regulator of cytokinesis 1 isoform 2

    See proteins identical to NP_955445.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC068831, AK312600, BX647317, DA655494, DW423775
    Consensus CDS
    CCDS45352.1
    Conserved Domains (2) summary
    pfam03999
    Location:37601
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 

    Range
    90966038..90994651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720760.1XP_006720823.1  

    Conserved Domains (2) summary
    pfam03999
    Location:37560
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  2. XM_005254987.1XP_005255044.1  

    UniProtKB/TrEMBL
    F8W9B5
    Conserved Domains (2) summary
    pfam03999
    Location:37564
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  3. XM_006720759.1XP_006720822.1  

    Conserved Domains (2) summary
    pfam03999
    Location:37563
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  4. XM_005254986.1XP_005255043.1  

    Conserved Domains (2) summary
    pfam03999
    Location:37597
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase

Alternate HuRef

Genomic

  1. AC_000147.1 

    Range
    67620243..67648754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 

    Range
    91350870..91379451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199414.1: Suppressed sequence

    Description
    NM_199414.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.