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    LPP LIM domain containing preferred translocation partner in lipoma [ Homo sapiens (human) ]

    Gene ID: 4026, updated on 3-Jan-2016
    Official Symbol
    LPPprovided by HGNC
    Official Full Name
    LIM domain containing preferred translocation partner in lipomaprovided by HGNC
    Primary source
    HGNC:HGNC:6679
    See related
    Ensembl:ENSG00000145012; HPRD:02828; MIM:600700; Vega:OTTHUMG00000156387
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Orthologs
    Location:
    3q28
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (188152143..188890671)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (187871097..188608460)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374266 Neighboring gene uncharacterized LOC105374268 Neighboring gene LPP antisense RNA 2 Neighboring gene uncharacterized LOC401105 Neighboring gene LPP antisense RNA 1 Neighboring gene microRNA 28 Neighboring gene TPRG1 antisense RNA 1 Neighboring gene enolase-phosphatase 1 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    NHGRI GWA Catalog
    A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
    NHGRI GWA Catalog
    Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
    NHGRI GWA Catalog
    Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese.
    NHGRI GWA Catalog
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    NHGRI GWA Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    NHGRI GWA Catalog
    Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region.
    NHGRI GWA Catalog
    Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
    NHGRI GWA Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    NHGRI GWA Catalog
    Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
    NHGRI GWA Catalog
    Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
    NHGRI GWA Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    NHGRI GWA Catalog
    Newly identified genetic risk variants for celiac disease related to the immune response.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.
    NHGRI GWA Catalog
    White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of LIM domain containing preferred translocation partner in lipoma (LPP) by siRNA enhances HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ30652, FLJ41512, DKFZp779O0231

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    lipoma-preferred partner
    Names
    LIM protein
    lipoma preferred partner

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016932.2 RefSeqGene

      Range
      4999..741797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001167671.2NP_001161143.1  lipoma-preferred partner isoform a

      See identical proteins and their annotated locations for NP_001161143.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC009319, AI126032, AW301088, BC144076, KF510228, U49957
      Consensus CDS
      CCDS3291.1
      UniProtKB/TrEMBL
      B7ZLW0
      UniProtKB/Swiss-Prot
      Q93052
      Related
      ENSP00000478901, ENST00000617246
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    2. NM_001167672.2NP_001161144.1  lipoma-preferred partner isoform b

      See identical proteins and their annotated locations for NP_001161144.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains alternate 5' exon structure and thus differs in the 5' UTR, and it uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AC009319, AI126032, AK304035, AW301088, CD697098, KF510228
      UniProtKB/TrEMBL
      B7Z8W0
      Conserved Domains (4) summary
      cd09350
      Location:269322
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:329381
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      pfam15245
      Location:79220
      VGLL4; Transcription cofactor vestigial-like protein 4
      cl02475
      Location:389454
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    3. NM_005578.4NP_005569.1  lipoma-preferred partner isoform a

      See identical proteins and their annotated locations for NP_005569.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC009319, AI126032, AW301088, KF510228, U49957
      Consensus CDS
      CCDS3291.1
      UniProtKB/Swiss-Prot
      Q93052
      Related
      ENSP00000482617, OTTHUMP00000275866, ENST00000618621, OTTHUMT00000344030
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

      Range
      188152143..188890671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512828.1XP_011511130.1  

      See identical proteins and their annotated locations for XP_011511130.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    2. XM_011512824.1XP_011511126.1  

      See identical proteins and their annotated locations for XP_011511126.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    3. XM_005247450.3XP_005247507.1  

      See identical proteins and their annotated locations for XP_005247507.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    4. XM_011512834.1XP_011511136.1  

      See identical proteins and their annotated locations for XP_011511136.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    5. XM_005247446.3XP_005247503.1  

      See identical proteins and their annotated locations for XP_005247503.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    6. XM_011512827.1XP_011511129.1  

      See identical proteins and their annotated locations for XP_011511129.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    7. XM_011512833.1XP_011511135.1  

      See identical proteins and their annotated locations for XP_011511135.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    8. XM_005247451.3XP_005247508.1  

      See identical proteins and their annotated locations for XP_005247508.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    9. XM_011512830.1XP_011511132.1  

      See identical proteins and their annotated locations for XP_011511132.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    10. XM_011512831.1XP_011511133.1  

      See identical proteins and their annotated locations for XP_011511133.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    11. XM_011512820.1XP_011511122.1  

      See identical proteins and their annotated locations for XP_011511122.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    12. XM_011512821.1XP_011511123.1  

      See identical proteins and their annotated locations for XP_011511123.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    13. XM_011512822.1XP_011511124.1  

      See identical proteins and their annotated locations for XP_011511124.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    14. XM_011512832.1XP_011511134.1  

      Conserved Domains (2) summary
      PRK14086
      Location:191380
      dnaA; chromosomal replication initiation protein; Provisional
      PRK14971
      Location:141219
      PRK14971; DNA polymerase III subunits gamma and tau; Provisional
    15. XM_011512835.1XP_011511137.1  

      See identical proteins and their annotated locations for XP_011511137.1

      Conserved Domains (2) summary
      PRK14086
      Location:191380
      dnaA; chromosomal replication initiation protein; Provisional
      PRK14971
      Location:141219
      PRK14971; DNA polymerase III subunits gamma and tau; Provisional
    16. XM_005247453.1XP_005247510.1  

      See identical proteins and their annotated locations for XP_005247510.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    17. XM_011512829.1XP_011511131.1  

      See identical proteins and their annotated locations for XP_011511131.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    18. XM_011512823.1XP_011511125.1  

      Conserved Domains (3) summary
      cd09350
      Location:441494
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:501553
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:561626
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    19. XM_011512826.1XP_011511128.1  

      See identical proteins and their annotated locations for XP_011511128.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    20. XM_011512825.1XP_011511127.1  

      See identical proteins and their annotated locations for XP_011511127.1

      UniProtKB/Swiss-Prot
      Q93052
      Conserved Domains (3) summary
      cd09350
      Location:416469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:476528
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:536601
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    21. XM_011512836.1XP_011511138.1  

      See identical proteins and their annotated locations for XP_011511138.1

      UniProtKB/TrEMBL
      B7Z871
      Conserved Domains (3) summary
      cd09350
      Location:253306
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09356
      Location:313365
      LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cl02475
      Location:373438
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      187834798..188571334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)