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    SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 [ Homo sapiens (human) ]

    Gene ID: 115584, updated on 5-Jul-2015
    Official Symbol
    SLC5A11provided by HGNC
    Official Full Name
    solute carrier family 5 (sodium/inositol cotransporter), member 11provided by HGNC
    Primary source
    HGNC:HGNC:23091
    See related
    Ensembl:ENSG00000158865; MIM:610238; Vega:OTTHUMG00000097003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KST1; RKST1; SGLT6; SMIT2
    Summary
    Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive active transport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002) [PubMed 12039040].[supplied by OMIM, Mar 2008]
    Orthologs
    See SLC5A11 in Epigenomics, MapViewer
    Location:
    16p12.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (24845863..24911628)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (24857184..24922949)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1567 Neighboring gene trinucleotide repeat containing 6A Neighboring gene Rho GTPase activating protein 17 Neighboring gene thyroid hormone receptor interactor 11 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    NHGRI GWA Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    NHGRI GWA Catalog
    Lupus nephritis susceptibility Loci in women with systemic lupus erythematosus.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
     
    sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane transport TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    sodium/myo-inositol cotransporter 2
    Names
    Na(+)/myo-inositol cotransporter 2
    SLC5A11
    homolog of rabbit KST1
    putative sodium-coupled cotransporter RKST1
    sodium-dependent glucose cotransporter
    sodium/glucose cotransporter KST1
    sodium/myo-inositol transporter 2
    solute carrier family 5 (sodium/glucose cotransporter), member 11

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258411.2NP_001245340.1  sodium/myo-inositol cotransporter 2 isoform 2

      See identical proteins and their annotated locations for NP_001245340.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AA772233, AK303691, AY044906, DC332171, KC877600
      Consensus CDS
      CCDS58437.1
      UniProtKB/TrEMBL
      B7Z8N3
      UniProtKB/Swiss-Prot
      Q8WWX8
      Related
      ENSP00000416782, ENST00000424767
      Conserved Domains (1) summary
      cl00456
      Location:28640
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. NM_001258412.2NP_001245341.1  sodium/myo-inositol cotransporter 2 isoform 3

      See identical proteins and their annotated locations for NP_001245341.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AA772233, AK295427, AY044906, DC332171, KC877600
      Consensus CDS
      CCDS58438.1
      UniProtKB/Swiss-Prot
      Q8WWX8
      Related
      ENSP00000441384, ENST00000545376
      Conserved Domains (1) summary
      cl00456
      Location:28605
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. NM_001258413.2NP_001245342.1  sodium/myo-inositol cotransporter 2 isoform 4

      See identical proteins and their annotated locations for NP_001245342.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal exon and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AA772233, AY044906, BC057780, DC332171, KC877600
      Consensus CDS
      CCDS58439.1
      UniProtKB/Swiss-Prot
      Q8WWX8
      Related
      ENSP00000457179, OTTHUMP00000256135, ENST00000565769, OTTHUMT00000435851
      Conserved Domains (1) summary
      cl00456
      Location:1611
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    4. NM_001258414.1NP_001245343.1  sodium/myo-inositol cotransporter 2 isoform 5

      See identical proteins and their annotated locations for NP_001245343.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences, including the use of a downstream start codon and a transient frameshift in the coding region, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AA772233, BC049385, DC332171
      Consensus CDS
      CCDS58440.1
      UniProtKB/Swiss-Prot
      Q8WWX8
      Related
      ENSP00000389606, ENST00000449109
      Conserved Domains (1) summary
      cl00456
      Location:1519
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    5. NM_052944.4NP_443176.2  sodium/myo-inositol cotransporter 2 isoform 1

      See identical proteins and their annotated locations for NP_443176.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA772233, AY044906, KC877600
      Consensus CDS
      CCDS10625.1
      UniProtKB/Swiss-Prot
      Q8WWX8
      Related
      ENSP00000289932, OTTHUMP00000122494, ENST00000347898, OTTHUMT00000214091
      Conserved Domains (1) summary
      cd11490
      Location:28675
      SLC5sbd_SGLT6; Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

      Range
      24845863..24911628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721015.1XP_006721078.1  

      Conserved Domains (1) summary
      cl00456
      Location:1576
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_005255080.2XP_005255137.1  

      See identical proteins and their annotated locations for XP_005255137.1

      UniProtKB/Swiss-Prot
      Q8WWX8
      Conserved Domains (1) summary
      cd11490
      Location:28675
      SLC5sbd_SGLT6; Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain
    3. XM_011545724.1XP_011544026.1  

      Conserved Domains (1) summary
      cl00456
      Location:29662
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    4. XM_011545723.1XP_011544025.1  

      Conserved Domains (1) summary
      cl00456
      Location:55688
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    5. XM_011545726.1XP_011544028.1  

      Conserved Domains (1) summary
      cl00456
      Location:55596
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    6. XM_011545725.1XP_011544027.1  

      Conserved Domains (1) summary
      cl00456
      Location:55653
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    7. XM_011545727.1XP_011544029.1  

      See identical proteins and their annotated locations for XP_011544029.1

      Conserved Domains (1) summary
      cl00456
      Location:1514
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    8. XM_005255082.3XP_005255139.1  

      See identical proteins and their annotated locations for XP_005255139.1

      Conserved Domains (1) summary
      cl00456
      Location:1514
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    9. XM_011545728.1XP_011544030.1  

      Conserved Domains (1) summary
      cl00456
      Location:1365
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      25871172..25936854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)