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    uvrC UvrABC excision nuclease subunit C [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947203, updated on 4-Apr-2024

    Summary

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    Gene symbol
    uvrC
    Gene description
    UvrABC excision nuclease subunit C
    Primary source
    ASAP:ABE-0006370
    Locus tag
    b1913
    See related
    ECOCYC:EG11063
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1912
    Summary
    UvrC is one of three (along with UvrA and UvrB) enzyme components participating in the nucleotide excision repair (NER) process. [More information is available at EcoCyc: EG11063].
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    Genomic context

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    Sequence:
    NC_000913.3 (1992874..1994706, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Neighboring gene DNA-binding transcriptional activator UvrY Neighboring gene protein YecU Neighboring gene DUF2594 domain-containing protein YecF Neighboring gene DNA-binding transcriptional dual regulator SdiA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interrogating the substrate specificity landscape of UvrC reveals novel insights into its non-canonical function. Thakur M, et al. Biophys J, 2022 Aug 16. PMID 35810330, Free PMC Article
    2. The C-terminal region of Escherichia coli UvrC contributes to the flexibility of the UvrABC nucleotide excision repair system. Verhoeven EE, et al. Nucleic Acids Res, 2002 Jun 1. PMID 12034838, Free PMC Article
    3. Sequence-dependent interactions of two forms of UvrC with DNA helix-stabilizing CC-1065-N3-adenine adducts. Nazimiec M, et al. Biochemistry, 2001 Sep 18. PMID 11551204
    4. Two forms of UvrC protein with different double-stranded DNA binding affinities. Tang Ms, et al. J Biol Chem, 2001 Feb 9. PMID 11056168
    5. The C-terminal region of the Escherichia coli UvrC protein, which is homologous to the C-terminal region of the human ERCC1 protein, is involved in DNA binding and 5'-incision. Moolenaar GF, et al. Nucleic Acids Res, 1998 Jan 15. PMID 9421501, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interrogating the substrate specificity landscape of UvrC reveals novel insights into its non-canonical function.
      Title: Interrogating the substrate specificity landscape of UvrC reveals novel insights into its non-canonical function.
    2. Recruitment of UvrBC complexes to UV-induced damage in the absence of UvrA increases bacterial survival.
      Title: Recruitment of UvrBC complexes to UV-induced damage in the absence of UvrA increases cell survival.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Two forms of UvrC protein with different double-stranded DNA binding affinities.
    4. In solution, two UvrB subunits bind to UvrA, most likely as part of a UvrA2B2 complex. The UvrA-induced dimerization of the C-terminal domain 4 regions of UvrB serves to shield these domains from premature UvrC binding.
      Title: Dynamics of the UvrABC nucleotide excision repair proteins analyzed by fluorescence resonance energy transfer.
    5. we examined the interaction of UvrABC with a DNA substrate containing a single G[8,5-Me]T cross-link and compared it with T[6,4]T (the 6-4 pyrimidine-pyrimidone photoproduct) and the C8 guanine adduct of N-acetyl-2-aminofluorene (AAF)
      Title: Recognition and incision of gamma-radiation-induced cross-linked guanine-thymine tandem lesion G[8,5-Me]T by UvrABC nuclease.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables excinuclease ABC activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SOS response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of excinuclease repair complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of excinuclease repair complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of excinuclease repair complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of excinuclease repair complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UvrABC excision nuclease subunit C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1992874..1994706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416423.4 UvrABC excision nuclease subunit C [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416423.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AHU8, A0A7D7KIK0, A0A895NVN1, A0A8H9XPE3
      Conserved Domains (1) summary
      PRK00558
      Location:8 → 610
      uvrC; excinuclease ABC subunit UvrC
    Nucleotide Protein
    Heading Accession and Version

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