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    HOXA13 homeobox A13 [ Homo sapiens (human) ]

    Gene ID: 3209, updated on 24-Apr-2016
    Official Symbol
    HOXA13provided by HGNC
    Official Full Name
    homeobox A13provided by HGNC
    Primary source
    HGNC:HGNC:5102
    See related
    Ensembl:ENSG00000106031 HPRD:00847; MIM:142959
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOX1; HOX1J
    Summary
    In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    7p15.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (27193419..27200266, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27236499..27239725, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene homeobox A11 Neighboring gene HOXA11 antisense RNA Neighboring gene HOXA distal transcript antisense RNA Neighboring gene EVX1 antisense RNA Neighboring gene even-skipped homeobox 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat specifically associates with HOXA13 promoter to upregulate HOXA13 expression in T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal system development TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    homeobox protein Hox-A13
    Names
    homeo box 1J
    homeo box A13
    homeobox protein HOXA13
    homeobox protein Hox-1J
    transcription factor HOXA13

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008181.1 RefSeqGene

      Range
      5001..8227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000522.4NP_000513.2  homeobox protein Hox-A13

      See identical proteins and their annotated locations for NP_000513.2

      Status: REVIEWED

      Source sequence(s)
      AC004080, BC016712, BC075791
      Consensus CDS
      CCDS5412.1
      UniProtKB/Swiss-Prot
      P31271
      UniProtKB/TrEMBL
      Q6DI00
      Related
      ENSP00000222753, OTTHUMP00000217287, ENST00000222753, OTTHUMT00000358752
      Conserved Domains (2) summary
      cd00086
      Location:323379
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam12284
      Location:85224
      HoxA13_N; Hox protein A13 N terminal

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

      Range
      27193419..27200266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515344.1XP_011513646.1  

      See identical proteins and their annotated locations for XP_011513646.1

      UniProtKB/Swiss-Prot
      P31271
      Conserved Domains (2) summary
      cd00086
      Location:323379
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam12284
      Location:85224
      HoxA13_N; Hox protein A13 N terminal

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      27236223..27239448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)