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EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 [ Homo sapiens (human) ]

Gene ID: 1982, updated on 7-Dec-2014
Official Symbol
EIF4G2provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4 gamma, 2provided by HGNC
Primary source
HGNC:HGNC:3297
Locus tag
OK/SW-cl.75
See related
Ensembl:ENSG00000110321; HPRD:09084; MIM:602325; Vega:OTTHUMG00000165823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P97; AAG1; DAP5; NAT1
Summary
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
See EIF4G2 in Epigenomics, MapViewer
Location:
11p15
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (10797046..10809035, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (10818593..10830582, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MRVI1 antisense RNA 1 Neighboring gene murine retrovirus integration site 1 homolog Neighboring gene CTR9, Paf1/RNA polymerase II complex component Neighboring gene uncharacterized LOC101928053 Neighboring gene small nucleolar RNA, C/D box 97 Neighboring gene ZBED5 antisense RNA 1 Neighboring gene zinc finger, BED-type containing 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
    Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Diurnally regulated genes with circadian orthologs, organism-specific biosystem (from WikiPathways)
    Diurnally regulated genes with circadian orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
  • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
    ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Viral myocarditis, organism-specific biosystem (from KEGG)
    Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
  • eIF4F complex, organism-specific biosystem (from KEGG)
    eIF4F complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • eIF4F complex, conserved biosystem (from KEGG)
    eIF4F complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: ZBED5

Homology

Clone Names

  • FLJ41344

Gene Ontology Provided by GOA

Function Evidence Code Pubs
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation factor activity, nucleic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
cell death TAS
Traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic translation initiation factor 4F complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
eukaryotic translation initiation factor 4 gamma 2
Names
eukaryotic translation initiation factor 4 gamma 2
DAP-5
EIF4G2
eIF4G 2
eIF-4G 2
eIF-4-gamma 2
aging-associated protein 1
death-associated protein 5
eukaryotic translation initiation factor 4G-like 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042559.2NP_001036024.3  eukaryotic translation initiation factor 4 gamma 2 isoform 2

    See proteins identical to NP_001036024.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AI362365, BC111548, DB072494, DB272352
    Consensus CDS
    CCDS41618.1
    UniProtKB/Swiss-Prot
    P78344
    Related
    ENSP00000379778, OTTHUMP00000231229, ENST00000396525, OTTHUMT00000386606
    Conserved Domains (3) summary
    cd11559
    Location:702838
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    smart00544
    Location:506619
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    pfam02854
    Location:78308
    MIF4G; MIF4G domain
  2. NM_001172705.1NP_001166176.1  eukaryotic translation initiation factor 4 gamma 2 isoform 1

    See proteins identical to NP_001166176.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AI362365, BC065276, DB231980, DB272352
    Consensus CDS
    CCDS31428.1
    UniProtKB/Swiss-Prot
    P78344
    UniProtKB/TrEMBL
    Q2TU89
    Related
    ENSP00000433664, OTTHUMP00000231227, ENST00000526148, OTTHUMT00000386603
    Conserved Domains (3) summary
    cd11559
    Location:740876
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    smart00544
    Location:544657
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    pfam02854
    Location:78308
    MIF4G; MIF4G domain
  3. NM_001418.3NP_001409.3  eukaryotic translation initiation factor 4 gamma 2 isoform 1

    See proteins identical to NP_001409.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AI362365, AK223548, DB072494, DB272352
    Consensus CDS
    CCDS31428.1
    UniProtKB/Swiss-Prot
    P78344
    Related
    ENSP00000340281, OTTHUMP00000231076, ENST00000339995, OTTHUMT00000386384
    Conserved Domains (3) summary
    cd11559
    Location:740876
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    smart00544
    Location:544657
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    pfam02854
    Location:78308
    MIF4G; MIF4G domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    10797046..10809035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    10817553..10829619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    10491522..10503590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)